cefpirome


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cefpirome

A CEPHALOSPORIN ANTIBIOTIC drug. A brand name is Cefrom.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
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[12] Organisms over expressing Amp-C [beta]-lactamases are a major clinical concern, because these are usually resistant to all beta-lactam drugs except for cefepime, cefpirome and carbapenems.
A pannel of ccommercially available selected antibiotics discs including ciprofloxacin (CIP) 5 ug, piperacillin (PRL) 100 ug, oxacillin (OX) 1 ug, ampicillin (AM) ug, bacitracin (B) 10 U, methicillin (ME) 10 ug, amikacin (AK) 30 ug, vancomycin (VA) 30 ug, optochin (OP) 5 ug, amoxicillin (AX) 25 ug and cefpirome (CPO) 30 ug was used.
The antibiotics disks used and their concentrations were: cefoperazone (75[micro]g), cefixime (5[micro]g), cefpirome (30[micro]g), cefotaxime (30[micro]g), cefoxitin (30[micro]g) ceftriaxone (30), ceftazidime (30[micro]g), cefpodoxime (10 [micro]g), cefepime (30 [micro]g), ofloxacin (5jg), gentamicin (10 [micro]g), amikacin (30 [micro]g), gatifloxacin (5jg), aztreonam (30 [micro]g), imipenem (10 [micro]g), piperacillin/tazobactam (100/10[micro]g), and ceftriaxone/sulbactam (30/15[micro]g).
The isolates were also tested for resistance to ampicillin, cotrimoxazole, ciprofloxacin, ceftriaxone, doripenem, imipenem, ertapenem, aztreonam, moxifloxacin, cefpirome, cefepime, gatifloxacin, and chloramphenicol by Kirby-Bauer disc diffusion method.
AmpC-producing organisms become resistant to almost all [beta]-lactam antibiotics, with the exception of cefepime, cefpirome, and carbapenems.
Nikaido, "Mutation in Serratia marcescens AmpC beta-lactamase producing high-level resistance to ceftazidime and cefpirome," Antimicrobial Agents and Chemotherapy, vol.
The following antimicrobial disks were used to assess susceptibility testing: clavulanic acid 30mg / disk, piperacillin/tazobactam 110mg / disk, cefotaxime 30mg / disk, cefpirome 30mg / disk, cefuroxime 30mg / disk, vancomycin 30mg / disk, aztreonam 30mg / disk, imipenem 10mg / disk, amikacin 30mg / disk, gentamicin 10mg / disk, tobramycin 10mg / disk, erythromycin 15mg / disk, clarithromycin 15mg / disk, clindamycin 2mg / disk, ciprofloxacin 5mg / disk, chloramphenicol 30mg / disk, sulphamethoxazole 25mg / disk, fosfomycin 50mg / disk, fusidic acid 10mg / disk by OXOID.
The following antibiotic susceptibilities were reported: [beta]-lactams (ticarcillin, ticarcillin/clavulanate, ceftazidime, cefepime, and cefpirome); aminoglycosides (amikacin, gentamicin, isepamicin, netilmicin, and tobramycin); fluoroquinolones (ciprofloxacin, levofloxacin, and pefloxacin); carbapenems (imipenem and meropenem); extended-spectrum [beta]-lactams (aztreonam, piperacillin, andpiperacillin/tazobactam); sulfonamides (trimethoprim/sulfamethoxazole); tetracyclines (minocycline), and polymyxins (colistin).
(70%) trimethoprim / sulphamethoxazole (69%) cefpirome (68%) and ciprofloxacin (60%) as shown in Table-III.All MRSA pathogens showed susceptibility to vancomycin (100%) imipenem (81%) and doxycycline (55%) but were found highly resistant to cefpirome and erythromycin (98%) clarithromycin chloramphenicol and ciprofloxacin (93%) fosfomycin fusidic acid and trimethoprim/ sulphamethoxazole (83%) sulbactam/ cefoperazone (81%) clindamycin (76%) amikacin (67%) and piperacillin / tazobactam (60%) as shown in Table-III.
(15) Most ESBLs can also hydrolyze fourth-generation cephalosporins (e.g., cefepime or cefpirome).
Ashhurst-Smith, "Comparative in vitro susceptibility of Burkholderia pseudomallei to cefpirome, ceftazidime and cefepime," Pathology, vol.
The 43 Enterobacteriaceae were slightly more susceptible, with 52% of isolates resistant to cefotaxime, 21% to cefpirome, 47% to aztreonam, 40% to amikacin, 19% to ciprofloxacin, and 2% to imipenem [24].