CDK2


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CDK2

A gene on chromosome 12q13 that encodes a Ser/Thr kinase, which is the catalytic subunit of the cyclin-dependent protein kinase complex. CDK2 activity is restricted to the G1-S phase, and is essential for G1/S phase transition in the cell cycle. CDK2 associates with, and is regulated by, the regulatory subunits of the complex (cyclin A or E), CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B); its activity is regulated by phosphorylation.
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2] value between CDK2 and RBL1 in 4 RNA samples is around 0.
Variability of the reverse transcription step: practical implications
Explant-induced reactivation of herpes simplex virus occurs in neurons expressing nuclear cdk2 and cdk4.
Estimation of homozygote recessive and heterozygous CDK3 distribution in randomly selected cancer subjects
In general, when the INK group functions in the genetic pathway containing cyclin D-CDK4/6-pRb and E2F, the Cip/Kip group can inhibit CDK2 kinase and CDK4/6 (9), (10).
Flow cytometric evaluation of cell cycle regulators (cyclins and cyclin-dependent kinase inhibitors) expressed on bone marrow cells in patients with chronic myeloid leukemia and multiple myeloma / Kronik Miyelositer Losemi ve Multipl Miyelom Olgularmdaki Kemik Iligi Kaynakh Hucrelerde, Hucre Siklusu Duzenleyicilerinin (Siklinler ve Siklin Bagimli Kinaz Inhibitorleri) Alum Sitometrik Olarak Degerlendirilmesi
Outro possivel mecanismo de acao e a inibicao da adipogenese pela EGCG devido ao seu envolvimento com a modulacao mitotica da proteina quinase (MAP), especialmente em sinais regulatorios extracelulares (ERK), que estimulam o fator de crescimento e a via CDK2, enzima chave para o processo da mitogenese.
The role of green tea on the body composition of obese sedentary subjects/O papel do cha verde na alteracao da composicao corporal de individuos obesos sedentarios
The human papillomavirus E7 oncoprotein can uncouple cellular differentiation and proliferation in human keratinocytes by abrogating p21Ciplmediated inhibition of cdk2.
Cell intrinsic & extrinsic factors in cervical carcinogenesis
Paraffin-embedded specimens from inactive endometrium (n = 16), endometrial hyperplasia (n = 23) and endometrioid endometrial carcinoma (n = 39) were stained immunohistochemically for cyclin A, cyclin B1, cyclin D1, cyclin E, cdk2, p16, p21, p27, p53 and Ki67(MIB-1).
Cell cycle alterations in endometrial carcinoma
More necently, erythrosin B (dose range: 25-100 [micro]g/mL) has been shown to stimulate proliferation in estrogen receptor (ER) positive HTB 133 cells and to increase Cdk2 activity (dose range: 3-10 [micro]g/mL) in MCF7 cells (Dees et al.
Estrogenicity of the syntheic food colorants tartrazine, erythrosin B, and sudan I in an estrogen-responsive human breast cancer cell line
Estudios preclinicos han demostrado la eficacia del mifepristone para inhibir el crecimiento del cancer epitelial de ovario, a traves de la activacion de inhibidores de la ciclina dependiente de quinasa (cdk) y la reducida trascripcion de factores que expresan cdk2 y ciclinas A y E.
Antagonistas de receptores de progesterona (PRA) y moduladores selectivos de receptores de progesterona (SPRM): aplicaciones en ginecologia y obstetricia
Um possivel mecanismo de acao e a epigalocatequina galato induzindo a inibicao da adipogenese pode estar envolvido com a modulacao mitotica da proteina quinase (MAP), especialmente sinais regulatorios extracelulares (ERK) que estimulam fatores de crescimento e da via Cdk2, tambem enzima chave para o processo de mitogenese (Lin e colaboradores, 2005; Hung e colaboradores, 2005).
Interaction of the daily ingestion of green tea (Camellia sinensis) in the cellular metabolism and the adipose cell promoting loss of weight/Interacao da ingestao diaria de cha verde (Camellia sinensis) no metabolismo celular e na celula adiposa promovendo emagrecimento
Morgan and Sung-Hou Kim of the University of California at Berkeley had previously determined the structure of CDK2.
Structure of protein-enzyme complex found
We observed that berberine treatment significantly decreased the expression of cydin D1, cydin E, CDK2, and CDK4 (cydin dependent kinases).
Berberine induces neuronal differentiation through inhibition of cancer stemness and epithelial-mesenchymal transition in neuroblastoma cells

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