CDK1

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CDK1

A gene on chromosome 10q21.1 that encodes a Ser/Thr protein kinase family, a catalytic subunit of the conserved complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins associate with CDK1, controlling its activity by cyclin accumulation and destruction through the cell cycle; phosphorylation and dephosphorylation of CDK1 play important regulatory roles in controlling the cell cycle.
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The present data also showed upregulation at the mRNA level of cell cycle regulatory genes ANAPC2, ABL-1, CDC2, CDK4, and CDK6 in RMCMO overexpressing SOX2.
GSK3, PKC, PKA, 14-3-3 Mode 1, PKG, p38MAPK, cdk5, CKII, cdc2, ATM, and CKI are the most predicted kinases involved in phosphorylation of many serine and threonine residues in IRS-2.
Wolfraim et al., "Cell cycle regulation of the cyclin A, cdc25C and cdc2 genes is based on a common mechanism of transcriptional repression," The EMBO Journal, vol.
SPBB tetrapeptides are target sites of phosphorylation by cdc2 (Poccia and Green, 1992), and they may subsequently become a target of (S/TP)-phosphorylation-dependent pep-tidyl-prolyl isomerases such as [peptidyl-prolyl cis-trans isomerase NIMA (never in mitosis gene a)-interacting ii Pini (Shen et al., 1998) before a final unique, highly ordered chromatin condensation takes place in the mature sperm of these organisms (Athey et al., 1990; Woodcock, 1994).
(2006) Involvement of Cdc2 in axonal regeneration enhanced by exercise training in rats.
Constitutive activation of p38 and downstream MK2 lead to an inhibitory phosphorylation event on the phosphatase CDC25C, inhibition of Cdc2, G2/M checkpoint maintenance, and chemoresistance.
Notably, genes required for G1/S transition were overrepresented in our array data, including CDKN1A, CCND1, CDK2, CDK4, MCM5, CDC2, CDC25A, and CDC25C (Figure 3) suggesting a cell cycle arrest in the G0/G1 phase.
Apigenin causes G(2)/M arrest associated with the modulation of p21(Cip1) and Cdc2 and activates p53-dependent apoptosis pathway in human breast cancer SK-BR-3 cells.
Several genes were differentially expressed: either down-regulated in cancer cells (UBE1L, CCND2) or upregulated (CHEK1/CHK1, CCNH, CCNB1, p18-CDKN2C, CDC2, FOXM1, CDC6).
Topoisomerase II A (TOP2A) and cell division cycle 2 (CDC2) showed the highest median upregulation in both stage >T1 tumours and stage Ta to T1 tumours, and also showed the least overlap between normal and tumour tissues, and their expressions in 93% of >T1 tumours and 88% of Ta to T1 tumours were greater than the 95th percentile of the expression in normal urothelium.