CTLA-4, also known as CD152
, is upregulated in T-cells after activation and plays an important negative regulatory role in the immune system.
Alterations of the expression of T-cell-related costimulatory CD28 and downregulatory CD152
(CTLA-4) molecules in patients with B-cell chronic lymphocytic leukaemia.
Maybe the most promising modulator of the B7/CD28-CTLA-4 pathway currently under investigation is CTLA-4-Ig, a chimeric protein consisting of the extracellular domain of human CD152
fused to the Fc region of human IgG-1.
Gene name U60145 Fragile X mental retardation 1 X67108 Brain derived neurothrophic factor L20682 Erythroblastosis virus E26 oncogene homolog 1 (avian) M12492 Type IIb subunit of cAMPdependent protein kinase U09401 Tenascin C M31178 Calbindin 1 M85301 Solute carrier family 9, member 4 M35162 Gamma-aminobutyric acid A receptor, delta S39221 N-methyl-D-aspartate receptor U89514 Calpain 9 AA866238 Similar to Acyl carrier protein, mitochondrial precursor U90271 CD152
antigen AB019576 Timeless (Drosophila) homolog Z22607 Bone morphogenetic protein 4 AF083331 Kinesin family member IB A1639073 Similar to Cadherin-related neuronal receptor Acc.
Results: The levels of CD152 in Group A showed an upward trend from the 3[sup]rd to 7[sup]th day, with a downward trend from the 7[sup]th to 14[sup]th day (20.
The levels of CD152 in Group A at postoperative days 3 and 7 were obviously higher than those in Groups B and C, while no significant difference could be found among values in the three groups at postoperative day 14.