In previous studies, it has been shown that PDE5 inhibitors reduced the formation of cavernosal fibrosis effectively, which led to prevention of PPED [4-7].
In histopathological examination, the intensity of cavernosal fibrosis was graded and distribution among groups was performed.
Chronically, this impairment may result in cavernosal fibrosis
, which may lead to permanent ED [8, 9].
Patients with anatomical deformation of the penis (such as angulation, cavernosal fibrosis
, or Peyronie's disease or conditions which predispose them to priapism (such as sickle cell anemia, multiple myeloma, or leukemia) should use sildenafil with caution.