In previous studies, it has been shown that PDE5 inhibitors reduced the formation of cavernosal fibrosis effectively, which led to prevention of PPED [4-7].
In histopathological examination, the intensity of cavernosal fibrosis was graded and distribution among groups was performed.
Chronically, this impairment may result in
cavernosal fibrosis, which may lead to permanent ED [8, 9].
Patients with anatomical deformation of the penis (such as angulation,
cavernosal fibrosis, or Peyronie's disease or conditions which predispose them to priapism (such as sickle cell anemia, multiple myeloma, or leukemia) should use sildenafil with caution.