Caveolins and flotillins are two families of the membrane proteins correlating with Caveolae of the mammals (Bickel et al.
Caveolae, caveolins, and cavins: complex control of cellular signalling and inflammation.
Caveolins (Cav) are essential components of caveolae, which are plasma membrane invaginations that demonstrate reduced fluidity; this reflects an accumulation of cholesterol .
Hong, "Differential expression of caveolins and myosin heavy chains in response to forced exercise in rats," Laboratory Animal Research, vol.
These tumors express basal/ myoepithelial cell genes, such as CK5, CK14, CK17, caveolins
1 and 2, nestin, P-cadherin, CD44, and EGFR.
, liquid-ordered domains, and signal transduction.
Kichler and co-workers reported a low level of luciferase expression in HepG2 cells transfected with polyplex due to lack of endogenous caveolins
and demonstrated that in these cells most of the internalized DNA was degraded in intracellular compartments because of clathrin-mediated endocytosis (27).
Role of caveolae and caveolins
in health and disease.
Nichols, "Exploring the caves: cavins, caveolins
and caveolae," Trends in Cell Biology, vol.
are a 3member protein family with a dual and opposite role in cancer development, as they are implicated in both tumor suppression and oncogenesis.
Sowa, "Caveolae, caveolins
, cavins, and endothelial cell function: new insights," Frontiers in Physiology, vol.
The immunophenotype of basal-like tumors, as defined by GEP or by IHC surrogate markers, is characterized by positive expression of basal CKs, EGFR, p53, P-cadherin, caveolins
1 and 2, cyclin E, Ki-67, c-Kit, fascin, Sox2, moesin, vimentin, nestin, and laminin (Figure 2).