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The 22-kD transmembrane protein associated with the membranes of caveolae and with Golgi membranes; believed to function in signal transduction, in cholesterol transport, and metabolism of the cell.
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References in periodicals archive ?
Kurzchalia, "Getting rid of caveolins: phenotypes of caveolin-deficient animals," Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, vol.
Park et al., "Caveolin 1 expression correlates with poor prognosis and focal adhesion kinase expression in gastric cancer," Pathobiology, vol.
The increased levels of caveolin 1 in MVE has a cardioprotective effect in ischemia/reperfusion-induced damage, probably due to the increased endothelial NO release [5].
(1999) reported that caveolin might participate in membrane-GH/GHR internalization.
Balligand, "The regulation of endothelial nitric oxide synthase by caveolin: a paradigm validated in vivo and shared by the 'endothelium-derived hyperpolarizing factor'," Pflugers Archiv, vol.
Caveolae are cholesterol-rich microdomains of PM formed by caveolin protein that are likely assembled in Golgi and transported to the PM.
Evidence that p58CFGR and p53/56LYN redistributed to a Triton X-100-insoluble cytoskeletal fraction, also enriched in the caveolar protein caveolin, display an enhanced kinase activity," FEBS Letters, vol.
Zhao, "The expression and functionality of stromal caveolin 1 in human adenomyosis," Human Reproduction, vol.
[4] Human genes: APOA5, apolipoprotein A-V; PDGFRB, platelet-derived growth factor receptor beta; LDLRAP1, low density lipoprotein receptor adaptor protein 1; MMP9, matrix metallopeptidase 9; VEGFA, vascular endothelial growth factor A; ACTA2, actin, alpha 2, smooth muscle, aorta; APOC3, apolipoprotein C-III; CAV1, caveolin 1; CD40, CD40 molecule; CETP, cholesterol ester transfer protein, plasma; CIITA, class II, major histocompatibility complex, transactivator; FGG, fibrinogen gamma chain; GPX1, glutathione peroxidase 1; LPL, lipoprotein lipase; MBL2, mannose-binding lectin (protein C)2,soluble; MVK, mevalonate kinase; PITX2, paired like homeodomain 2; TNFRSF1A, tumor necrosis factor receptor superfamily, member 1A; UCP2, uncoupling protein 2 (mitochondrial, protein carrier).
Watanabe, "Caveolin involvement and modulation in breast cancer," Mini-Reviews in Medicinal Chemistry, vol.
Copies of a protein called caveolin cluster to help form caveolae, he adds.
Amlodipine increases endothelial nitric oxide release by modulating binding of native eNOS protein complex to caveolin. Eur J Pharmacol 2011; 659: 206-2012, doi: 10.1016/j.ejphar.2011.03.028.