CACNA1G

(redirected from Cav3.1)

CACNA1G

A gene on chromosome 17q22 that encodes the alpha-1G subunit of a voltage-dependent calcium channel, which mediates the entry of calcium ions into excitable cells. These channels are also involved in various calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and apoptosis. CACNA1G gives rise to T-type calcium channels that belong to the low-voltage activated (LVA) group, which are remarkable for opening at very negative potentials and for voltage-dependent inactivation. T-type channels are pacemakers for both central neurons and cardiac nodal cells, and support calcium signalling in secretory cells and vascular smooth muscle. They may be involved in modulating firing patterns of neurons, which is key to information processing as well as to cell growth.
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References in periodicals archive ?
In the current study, we detected the mRNA of the three isoforms of the T-type calcium channel CACNA1G (T-type [Ca.sup.2+] channel, Cav3.1), CACNA1H (T-type [Ca.sup.2+] channel, Cav3.2), and CACNA1I (T-type [Ca.sup.2+] channel, Cav3.3).
Arakawa et al., "Different distribution of Cav3.2 and Cav3.1 transcripts encoding T-type [Ca.sup.2+] channels in the embryonic heart of mice," Biomedical Research, vol.
Lee et al., "CaV3.1 is a tremorrhythm pacemaker in the inferior olive," Proceedings of the National Acadamy of Sciences of the United States of America, vol.
Monteil et al., "A recurrent mutation in CACNA1G alters Cav3.1 T-type calcium-channel conduction and causes autosomal-dominant cerebellar ataxia," American Journal of Human Genetics, vol.
Based on this clue, the scientists removed one type of calcium channel, Cav3.1, and looked at how the absence of that channel's activity affected mouse brain function.
The mice without working Cav3.1 calcium channels took longer to fall asleep than normal mice, and stayed asleep for much shorter periods.
Miyazaki et al., "Functional coupling between mGluR1 and Cav3.1 T-type calcium channels contributes to parallel fiber-induced fast calcium signaling within Purkinje cell dendritic spines," Journal of Neuroscience, vol.
(2006) observed that methylmercury inhibits the expression of the Cav3.1 of neuronal cells in the HEK 293 family.
Most recent studies have investigated L-type (CaV1.2) and T-type (CaV3.1) VGCCs in adult cultured NSCs and have detected their expression at the transcriptional or translational levels [37].