CACNA1E

(redirected from Cav2.3)

CACNA1E

A gene on chromosome 1q25-q31 that encodes the alpha-1E subunit of a voltage-dependent calcium channel, which mediates the entry of calcium ions into excitable cells. These channels are also involved in various calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and apoptosis. CACNA1E gives rise to R-type calcium channels that belong to the high-voltage activated (HVA) group, which may be involved in modulating firing patterns of neurons important for information processing.
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References in periodicals archive ?
CaV2.2 and CaV2.3 (N- and R-type) Ca2+ channels in depolarization-evoked entry of Ca2+ into mouse sperm.
Bali, "miR-34c-5p functions as pronociceptive microRNA in cancer pain by targeting Cav2.3 containing calcium channels," PAIN, vol.
In previous studies, David Adams and colleagues from RMIT University in Melbourne showed that Vc1.1 also acts through GABAB receptors to inhibit a second, mysterious class of neuronal VGCCs that have been implicated in pain signaling but have not been well understood-R-type (Cav2.3) channels.