Catharanthus alkaloids | definition of Catharanthus alkaloids by Medical dictionary
vinca alkaloids (redirected from Catharanthus alkaloids)
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vinca alkaloids [vin´kah]
a group of cytotoxic alkaloids extracted from the Madagascar periwinkle (Catharanthus roseus
G. Don or Vinca rosea
L.) and used as antineoplastic agents
; they are cell cycle specific for the M phase of cell division and disrupt the microtubules that form the spindle apparatus. The group includes vinblastine, vincristine, vindesine
, and vinorelbine
alkaloids such as vincristine and vinblastine (antitumor agents) extracted from the periwinkle plant.
vinca alkaloids A class of cytotoxic drugs used to treat various cancers. Examples are vindesine (Eldisine), vincristine (Oncovin) and vinblastine (Velbe).
References in periodicals archive
Consequently, in this study HL60 and K562 cells were used as representatives for AML and CML to assess the cytotoxicity of Catharanthus alkaloids against leukemia cells.
Previous studies have demonstrated that Catharanthus alkaloids induce apoptosis in a variety of malignant cells, including human melanoma, neuroblastoma and breast cancer cells (Huang et al.
Antiviral activity of selected Catharanthus alkaloids
. J Pharm Sci 1968; 57 : 2174-5.