vinca alkaloids

(redirected from Catharanthus alkaloids)
Also found in: Dictionary.

vinca alkaloids

 [vin´kah]
a group of cytotoxic alkaloids extracted from the Madagascar periwinkle (Catharanthus roseus G. Don or Vinca rosea L.) and used as antineoplastic agents; they are cell cycle specific for the M phase of cell division and disrupt the microtubules that form the spindle apparatus. The group includes vinblastine, vincristine, vindesine, and vinorelbine tartrate.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

Vinca al·ka·loids

alkaloids such as vincristine and vinblastine (antitumor agents) extracted from the periwinkle plant.
Farlex Partner Medical Dictionary © Farlex 2012

vinca alkaloids

A class of cytotoxic drugs used to treat various cancers. Examples are vindesine (Eldisine), vincristine (Oncovin) and vinblastine (Velbe).
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
References in periodicals archive ?
Consequently, in this study HL60 and K562 cells were used as representatives for AML and CML to assess the cytotoxicity of Catharanthus alkaloids against leukemia cells.
Previous studies have demonstrated that Catharanthus alkaloids induce apoptosis in a variety of malignant cells, including human melanoma, neuroblastoma and breast cancer cells (Huang et al.
Antiviral activity of selected Catharanthus alkaloids. J Pharm Sci 1968; 57 : 2174-5.