catenin

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ca·ten·in

(ka-tēn'in),
Cytoplasmic molecule that serves as a link between cadherins and the cytoskeleton of cells, allowing the formation of adherent junctions. There are two types: β-catenin, which is linked to the cadherin itself and α-catenin, which associates with actin microfilaments.
[L. catena, chain, + -in]

JUP

A gene on chromosome 17q21 that encodes a major cytoplasmic protein common to both submembranous plaques of desmosomes and intermediate junctions. JUP forms distinct complexes with cadherins, belongs to the catenin family and contains a distinct amino acid motif known as armadillo repeat.

Molecular pathology
JUP mutations are associated with Naxos disease.

ca·ten·in

(kă-tē'nin)
Cytoplasmic molecule that serves as a link between cadherins and the cytoskeleton of cells, allowing the formation of adherent junctions. There are two types: beta-catenin, which is linked to the cadherin itself, and alpha-catenin, which associates with actin microfilaments.
[L. catena, chain, + -in]

catenin

a PROTEIN initially characterized because of its association with the ACTIN of the CYTOSKELETON, where it acts as a bridging protein between CADHERIN and actin.
References in periodicals archive ?
As to noncanonical Wnt signaling components being expressed in primary neurons as a consequence of Wnt3a treatment, we intersected the 170 nominally differentially expressed genes with the reactome pathway "beta catenin independent Wnt signaling" including 143 genes belonging to PCP and/or [Ca.sup.2+] noncanonical pathways (DOI: 10.3180/REACT_172694.1).
EPLIN mediates linkage of the cadherin catenin complex to F-actin and stabilizes the circumferential actin belt.
Dynamic and static interactions between p120 catenin and E-cadherin regulate the stability of cell-cell adhesion.
Simultaneous loss of E-cadherin and catenins in invasive lobular breast cancer and lobular carcinoma in situ.
p120 catenin, which was initially described as a prominent substrate of the Src oncoprotein, (51) is encoded on band 11q11 and belongs to the catenin family.
The p120 catenin is an intracellular protein that promotes the binding between the complex of catenins and cell cytoskeleton.
[10] An alternative to reduce this interference and improve diagnosis is the combined use of immunohisto chemical markers of the catenin pathway.
Alison, "The expression of E-cadherin and catenins in colorectal tumours from familial adenomatous polyposis patients," Journal of Pathology, vol.
(1,2) The integrity and morphology of epithelial units is maintained by E-cadherin and its undercoat proteins, the catenins ([alpha], [beta], and [gamma]]g), which are associated with the cytoplasmic domain of E-cadherin.
Since the cadherins are known to associate intracellularly with catenins, we also examined whether [Beta]-catenin showed a similar pattern of nuclear reactivity in Merkel cell carcinomas.
Of these, the first two belong to the adherens junctions, where the adhesion molecules cadherin and catenin are present.