catenin


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ca·ten·in

(ka-tēn'in),
Cytoplasmic molecule that serves as a link between cadherins and the cytoskeleton of cells, allowing the formation of adherent junctions. There are two types: β-catenin, which is linked to the cadherin itself and α-catenin, which associates with actin microfilaments.
[L. catena, chain, + -in]

JUP

A gene on chromosome 17q21 that encodes a major cytoplasmic protein common to both submembranous plaques of desmosomes and intermediate junctions. JUP forms distinct complexes with cadherins, belongs to the catenin family and contains a distinct amino acid motif known as armadillo repeat.

Molecular pathology
JUP mutations are associated with Naxos disease.

ca·ten·in

(kă-tē'nin)
Cytoplasmic molecule that serves as a link between cadherins and the cytoskeleton of cells, allowing the formation of adherent junctions. There are two types: beta-catenin, which is linked to the cadherin itself, and alpha-catenin, which associates with actin microfilaments.
[L. catena, chain, + -in]

catenin

a PROTEIN initially characterized because of its association with the ACTIN of the CYTOSKELETON, where it acts as a bridging protein between CADHERIN and actin.
References in periodicals archive ?
The sections were stained for the following markers: Pancytokeratin (Leica Bond AE1/AE3), NSE (Leica Bond 22C9), CD56 (Leica Bond CD564), Vimentin (Leica Bond V9), CD10 (Leica Bond 56C6), progesterone receptor (Leica Bond 16), [beta] catenin (Leica Bond 17C2), chromogranin (VENTANA), synaptophysin (Leica) and CD99 (VENTANA O13).
The [alpha], [beta], p, and [gamma] catenins play important roles in intercellular signal transduction.
The amounts of CD31, VE cadherin, and [beta] catenin in celllysate and VEGF, E-selectin, MMP 9, and MMP 2 in medium were quantitated by ELISA.
These studies suggested that cadherin and catenin alterations cause deformation of the synapse and can affect long-term plasticity.
The scientists, led by Dr Eric Adams, have found a gene called catenin is altered in nearly all cases studied.
Medical experts claim the miracle chemical beta catenin could be used to "reprogramme" hairless adult skin to grow new folicles.
The merged image is an overlay of the DAPI and catenin images (scale bar = 50 [micro]m, mean [+ or -] SD, n = 3, ** p < 001).
Phosphorylation of AKT/PKB by CK2 is necessary for the AKT dependent up regulation of [beta] catenin transcriptional activity.
As to noncanonical Wnt signaling components being expressed in primary neurons as a consequence of Wnt3a treatment, we intersected the 170 nominally differentially expressed genes with the reactome pathway "beta catenin independent Wnt signaling" including 143 genes belonging to PCP and/or [Ca.sup.2+] noncanonical pathways (DOI: 10.3180/REACT_172694.1).
Caption: Figure 8: The role of SRT1720 and p53 in the downregulation of [beta]- catenin induced by LPS in HUVECs.