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A constituent of the catecholamines, epinephrine and norepinephrine, and dopa; used externally as an antiseptic.
Synonym(s): catechol (1) , pyrocatechin
Farlex Partner Medical Dictionary © Farlex 2012
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Antioxidant Water, pH 2.1 Trolox (1.4 [+ or -] 0.3) x [10.sup.5] (a) PMHC (1.9 [+ or -] 0.3) x [10.sup.5] (a) DBHA (f) (3.3 [+ or -] 0.4) x [10.sup.4] (a) Catechol (3 [+ or -] 1) x [10.sup.3] (a) Antioxidant Water, pH 7.4 Trolox (4.1 [+ or -] 0.7) x [10.sup.5] (a) PMHC (2.0 [+ or -] 0.3) x [10.sup.5] (a) DBHA (f) (3.2 [+ or -] 0.4) x [10.sup.4] (a) Catechol (7 [+ or -] 2) x [10.sup.3] (a) Antioxidant PhCl Trolox 1.1 x [10.sup.6] (b) PMHC 3.2 x [10.sup.6] (d) DBHA (f) 1.1 x [10.sup.5] (a) Catechol 5.5 x [10.sup.5] (g) Antioxidant MeCN Trolox (1.6 [+ or -] 0.2) x [10.sup.5] (c) PMHC 6.8 x [10.sup.5] (e) DBHA (f) 2.5 x [10.sup.4] (e) Catechol 2.5 x [10.sup.4] (d) (a) See [37]; (b) see [38]; (c) see [39]; (d) see [13]; (e) see [24]; (f) 2,6-di-tert-butyl-4-methoxyphenol; (g) see [40].
There is no doubt that the active principles of these compounds (8, 9) are the catechol functional moiety presented in the 3,4-dihydroxyphenyl ethanol and caffeic acid moieties in their structures.
chlorophenols and catechol decreased human membrane erythrocytes acetylcholinesterase activity [51] chlorophenol and dimethylphenol changed ATPase activity and membrane fluidity and also damaged membrane proteins [47-51].
Compound 7, with a catechol moiety and a conjugated carbonyl group, may be bound to free enzymes and form an enzyme substrate complex.
Current research spawned from our method applies LCED methodology to measure concentrations of other catechols such as isoproterenol, 2,3-dihydroxybenzoic acid (hydroxyl radical production), dihydroxyphenylacetic acid (main neuronal metabolite of dopamine), L-dihydroxyphenylserine (norepinephrine prodrug), and dihydroxyphenylacetaldehyde (cytotoxic metabolite of dopamine).
Early on in this work, we settled on catechols (or ortho-hydroxyphenols) as the most promising target for the synthetic work.
Free phenolics or catechols with orthodihydroxy compounds function effectively as iron-reducing chelators (Goodell et al.
Among others, the amphiphilic phenolic compounds, monohydroxyphenols and o-dihydroxyphenols (catechols), are extracted.
Generally, quinones and catechols used at levels less than 0.05% (500 ppm) can function as inhibitors by inactivating free radicals generated at the unsaturated sites in the resin or monomer.
The most popular are 2.4-dichlorophenoxyacetic acid (2,4-D) [8], 4-chloro-2-methylphenoxyacetic acid (mcPA) [25] and 2,4,5-trichloro-phenoxyacetic acid (2,4,5-T) that biodegradation leads to the formation of both phenols (phenol, 2-chlorophenol and 2,4-dichlorophenol) and catechols (catechol and 4,6-dichloro-catechol).
coli BL21 harboring c23oB61 gene (this work) pUC19 c23oB61 [Amp.sup.r], pUC19 derivative, c23oB61 encoding mutant form of catechol 2,3- dioxygenase (C103R, K289Stop) [22] pET-22(b) [Amp.sup.r]; Novagen pc23oB61 [Amp.sup.r], pET-22(b) derivative, c23oB61 encoding mutant form of catechol 2,3-dioxygenase (C103R, K289Stop) (this work) TABLE 2: Specific and relative activity of wild-type (wt) and mutant C23O dioxygenases using different catechols as the substrate.
Anti-inflammatory effects of catechols in lipopolysaccharide-stimulated microglia cells: inhibition of microglial neurotoxicity.