catechol O-methyltransferase

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cat·e·chol O-meth·yl·trans·fer·ase

a transferase that catalyzes the methylation of the hydroxyl group at the 3 position of the aromatic ring of catechols, including the catecholamines norepinephrine and epinephrine (thus, converting to normetanephrine and metanephrine, respectively), the methyl group coming from S-adenosyl-l-methionine. An important step in the catabolism of the catecholamines.
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References in periodicals archive ?
COMT (catechol-O-methyl transferase) activity is enhanced by progesterone also increasing turnover of dopamine, epinephrine, norepinephrine, and serotonin.
The Management of Early Parkinson's disease (11) includes adjuvant therapy to levodopa with a dopamine agonist, a MAOB inhibitor or a catechol-O-methyl transferase (COMT) inhibitor (Table 3).
Catechol-O-methyl transferase (COMT) gene haplotypes in Mexican and Spanish patients with fibromyalgia.