Our previous preclinical, translational and pilot clinical studies demonstrated that novel iron chelation therapy with the prototypic drug deferiprone (DFP) (i) induces neuroprotection in cell models of PD via a powerful antioxidant effect, (ii) reduces regional siderosis of the brain, (iii) reduces motor handicap via inhibition of catechol-o-methyl transferase
, and (iv) slows the progression of motor handicap in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model and in early PD patients.
COMT (catechol-O-methyl transferase
) activity is enhanced by progesterone also increasing turnover of dopamine, epinephrine, norepinephrine, and serotonin.
The Management of Early Parkinson's disease (11) includes adjuvant therapy to levodopa with a dopamine agonist, a MAOB inhibitor or a catechol-O-methyl transferase
(COMT) inhibitor (Table 3).
Sildenafil citrate rescues fetal growth in the catechol-O-methyl transferase
knockout mouse model.
(COMT) gene haplotypes in Mexican and Spanish patients with fibromyalgia.