active site

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ac·tive site

that portion of an enzyme molecule at which the actual reaction proceeds; considered to consist of one or more residues or atoms in a spatial arrangement that permits interaction with the substrate to effect its reaction.
Farlex Partner Medical Dictionary © Farlex 2012

active site

The part of an enzyme at which catalysis of the substrate occurs.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

Active Site

The site in an enzyme where a substrate binds and an enzymatic reaction—e.g., ligation, oxidoreduction, etc.—occurs. The structure of the amino acid residues within the active site enhances substrate binding, substrate activation, and formation of a transition state.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

ac·tive site

(ak'tiv sīt)
That portion of an enzyme molecule at which the actual reaction proceeds; one or more residues or atoms in a spatial arrangement that permits interaction with the substrate.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

active site

1. The region of an ENZYME to which the substance being affected binds so as to undergo a catalyzed reaction.
2. The localized part of a protein to which a substrate binds.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
Active siteclick for a larger image
Fig. 11 Active site . Lock-and-key mechanism of enzyme activity.

active site

an area of ENZYME surface which has a shape complementary to a particular SUBSTRATE, enabling the enzyme and substrate to become temporarily bonded to form an enzyme-substrate complex. Such a lock-and-key mechanism explains the great specificity of enzymes for substrates and also why changes in enzyme three-dimensional shape (by pH, temperature) cause alterations to enzyme activity.
Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005

Patient discussion about active site

Q. Are there any nice activities for adults with autism? I've been helping a very nice man of 45 of years old and I'm looking for some new things I can do with him in our time together. any ideas?

A. Autistic people react wonderfully with animals. for instance- i saw a group of severe Autistic teenagers going to swim with dolphins. the effect was amazing! taking him to the zoo, or even to the park to feed ducks, pet dogs, whatever.. could have a great effect on him.
hope i helped!
tell me how it went.

Q. what is a passive smoking? and is it dangerous as an active?

A. Passive smoking is the exposure to cigarettes smoke emitted from cigarettes smoke by other person. It's dangerous and may increase the risk to several diseases similar to active smoking (one's exposure to smoke emitted from the cigarettes he or she is smoking) although the risk is of lower magnitude. Example for passive smoking is children of smokers etc.

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Q. i swim a lot ! what are the advantages of swimming over other sport activities? on what part of the body does it work the most ?

A. its a good workout but your not really going to burn as much calories as a regular work out.

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References in periodicals archive ?
(a-c) Structural representations of CaMKII's catalytic domain (green), autoregulatory domain (ARD) (blue), and hub domain (gray).
Serratia marcescens ChiA is the closest, structurally related, characterized enzyme (74% identity on amino acid level in the N-terminal and catalytic domain) (GenBank: ABI79317.1; Figure 2).
Wilson, "Structure of the complex of a yeast glucoamylase with acarbose reveals the presence of a raw starch binding site on the catalytic domain," FEBS Journal, vol.
S5A-H, all of the 5-OH, 11-OH, and 12-OH in WEL can be exposed to the catalytic domain of the enzyme and conjugated with glucuronic acid.
The results of docking and analysis of the active site also show that all ligand alpha-Patchouli alcohol isomers are in the catalytic domain. Thus all the compounds have the capability of blocking oxygenated reaction and reaction peroxides; currently substrate arachidonic acid becomes PGH2.
It competes with the catalytic domain of MG-ATP to inhibit tumor growth, metastasis and angiogenesis, thus inducing tumor cells apoptosis for anti-tumor.7 After treatment with Gefitinib, symptoms relieved rapidly, but drug was intermittently discontinued because of recurrent gastrointestinal bleeding.
Activating and dominant inactivating c-KIT catalytic domain mutations in distinct clinical forms of human mastocytosis.
The expression of LIPH have been described in several tissues including brain, heart, liver, spleen, lungs, kidneys, pancreas, small and large intestine, prostate, male and female gonads.9,15 Strong expression of the gene has been described in hair follicle and hair shaft.15 The LIPH protein has an N-terminal signal domain followed by a catalytic domain. The catalytic domain contains three putative catalytic residues ser154, asp178 and his248 encoded by exons 3, 4 and 6 respectively that are important for its catalytic activity.
Therefore, we report here the use of denaturing high performance liquid chromatography (dHPLC) and sequencing methods to screen for mutations in the nucleotide binding loop (P-loop), the catalytic domain and the activation loop of the ABL gene.
From the SCOP database it was found that all the caspase-3 proteins belongs to alpha and beta proteins and they are in the caspase catalytic domain family.
These proteins, derived from the catalytic domain of the proteins, are supplied as activated proteins (activation by APMA is not necessary).
Structure of the HIV-1 integrase catalytic domain complexed with an inhibitor: a platform for antiviral drug design.

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