However, we believe that the second mechanism may be advantageous to synthesize large RNA by primitive catalytic RNA
, and ribozymes with RNA ligation activity might have been an essential catalytic activity in t he RNA world.
Noting the diversity of potential chemical paths available to HMU, they argue that ancient catalytic RNA
would have had much greater "efficiency and versatility" than researchers have realized.
The 14 papers, revised to incorporate audience interaction, explore the folding pathways and mechanisms by which constituent residues interact to yield native catalytic RNA
molecules and functional proteins, and how ribosomes and other macromolecular complexes self- assemble.
The "RNA world" hypothesis, which assumes that the chemical processes leading to the appearance of life were carried out by RNA molecules, has stimulated interests in catalytic reactions involving oligonucleotides such as catalytic RNA
The uniform product of all such reactions is released pyrophosphate, and the RNA product has the attacking phosphate linked to the 5[prime] [Alpha]-phosphate of the catalytic RNA
. Thus, reaction with free GDP yields pyrophosphate plus a congener of the eukaryotic message cap (1):
In another anti-gene approach, scientists make their own ribozymes--bits of catalytic RNA
that chew up other strings of this nucleic acid (SN: 12/22&29/90, p.390).
Wally Bugg won Outstanding Undergraduate Presentation award for his work on the "Isolation of a Catalytic RNA
Capable of Coenzyme Synthesis" conducted under the direction of Faqing Huang (University of Southern Mississippi.) In addition to the certificate, Mr.
In order to demonstrate the ability of RNA to catalyze the synthesis of coenzymes from their precursors, catalytic RNA
is being isolated by powerful in vitro selection/amplification techniques from a pool of random RNA sequences.
He reported using chemical "selection pressures" to coax an actual ribozyme -- a segment of catalytic RNA
that cuts itself out of a longer RNA molecule -- to evolve into a form that cuts DNA molecules instead.