ribozyme

(redirected from Catalytic RNA)
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ri·bo·zyme

(rī'bō-zīm),
A nonprotein RNA biocatalyst; several cleave precursors of tRNA to yield functional tRNAs; others act on rRNA; plays a key role in intron splicing events.
Synonym(s): organic catalyst (1) , RNA enzyme
[ribonucleic acid + -zyme]

ribozyme

(rī′bə-zīm′)
n.
An RNA molecule that acts as a catalyst, especially for the cleavage of RNA strands at specific sites.

ribozyme

One of a unique class of RNA molecules that can act as cleaving enzymes in addition to storing genetic information. This is a notable exception to the general rule that all enzymes are proteins. Ribozymes form complementary base pairs in the normal manner but can cleave segments of nascent RNA during the splicing process of the formation of mature RNA transcripts of DNA. Ribozymes can be used in various ways as treatment modalities.

ribozyme

an RNA molecule with catalytic activity. Ribozymes include (a) molecules involved in processing RNA precursor molecules by cleaving PHOSPHODIESTER BONDS, for example in self-SPLICING of some precursor rRNA INTRONS; and (b) molecules catalysing key cellular reactions, for example rRNA of the large ribosomal subunit (see RIBOSOME), which is closely involved with the peptidyl transferase activity that catalyses PEPTIDE BOND formation in TRANSLATION. Ribozymes are found in EUCARYOTES, PROKARYOTES, VIRUSES and VIROIDS.
References in periodicals archive ?
However, we believe that the second mechanism may be advantageous to synthesize large RNA by primitive catalytic RNA, and ribozymes with RNA ligation activity might have been an essential catalytic activity in t he RNA world.
Noting the diversity of potential chemical paths available to HMU, they argue that ancient catalytic RNA would have had much greater "efficiency and versatility" than researchers have realized.
The 14 papers, revised to incorporate audience interaction, explore the folding pathways and mechanisms by which constituent residues interact to yield native catalytic RNA molecules and functional proteins, and how ribosomes and other macromolecular complexes self- assemble.
The "RNA world" hypothesis, which assumes that the chemical processes leading to the appearance of life were carried out by RNA molecules, has stimulated interests in catalytic reactions involving oligonucleotides such as catalytic RNA (ribozyme).
The uniform product of all such reactions is released pyrophosphate, and the RNA product has the attacking phosphate linked to the 5[prime] [Alpha]-phosphate of the catalytic RNA. Thus, reaction with free GDP yields pyrophosphate plus a congener of the eukaryotic message cap (1):
In another anti-gene approach, scientists make their own ribozymes--bits of catalytic RNA that chew up other strings of this nucleic acid (SN: 12/22&29/90, p.390).
Wally Bugg won Outstanding Undergraduate Presentation award for his work on the "Isolation of a Catalytic RNA Capable of Coenzyme Synthesis" conducted under the direction of Faqing Huang (University of Southern Mississippi.) In addition to the certificate, Mr.
In order to demonstrate the ability of RNA to catalyze the synthesis of coenzymes from their precursors, catalytic RNA is being isolated by powerful in vitro selection/amplification techniques from a pool of random RNA sequences.
He reported using chemical "selection pressures" to coax an actual ribozyme -- a segment of catalytic RNA that cuts itself out of a longer RNA molecule -- to evolve into a form that cuts DNA molecules instead.

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