Castleman disease

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Castleman disease

a benign or premalignant condition resembling lymphoma but without recognizable malignant cells; there are isolated masses of lymphoid tissue and lymph node hyperplasia, usually in the abdominal or mediastinal area.

be·nign giant lymph node hy·per·pla·si·a

solitary masses of lymphoid tissue containing concentric perivascular aggregates of lymphocytes, occurring usually in the mediastinum or hilar region of young adults; similar changes have been reported outside the mediastinum and, if associated with interfollicular sheets of plasma cells, may progress to lymphoma or plasmacytoma.

Castleman disease

[Benjamin Castleman, U.S. pathologist, 1906–1982]
An occasionally aggressive illness marked by excessive growth of lymphoid tissue either localized in a single lymph node group or in multiple regions of the body. Although the cause is not precisely known, its associations with acquired immunodeficiency syndrome, Kaposi's sarcoma, and human herpes virus 8 infection have led some experts to propose that it has an infectious basis. Localized disease responds well to surgical resection. Widespread disease can sometimes be treated effectively with chemotherapy.


Benjamin, U.S. pathologist, 1906-1982.
Castleman disease - solitary masses of lymphoid tissue containing concentric perivascular aggregates of lymphocytes. Synonym(s): benign giant lymph node hyperplasia; Castleman tumor
Castleman tumor - Synonym(s): Castleman disease
References in periodicals archive ?
Castleman Disease Collaborative Network is a global initiative dedicated to accelerating research and treatment for Castleman disease to improve survival for all patients with CD.
19 Van Rhee F, Stone K, Szmania S, et al: Castleman disease in the 21st century: An update on diagnosis, assessment, and therapy.
Brief communication: rituximab in HIV-associated multicentric Castleman disease.
Castleman disease exists in two distinct histologic variants--the hyaline vascular type and the plasma cell type.
Lymph nodes involved by multicentric Castleman disease among HIV-positive individuals are often involved by Kaposi sarcoma.
Castleman disease (CD) is a nonmalignant lymphoproliferative disorder of lymph node that usually occurs in young adults and children, with no sex predilection.
High incidence of Kaposi sarcoma-associated herpesvirus-relate non-Hodgkin lymphoma in patients with HIV infection and multicentric Castleman disease.
Castleman disease is an uncommon lymphoproliferative disorder that usually presents asymptomatically at a single site, most commonly the mediastinum; it is rare in the head and .
Follicular dendritic cell sarcoma is associated with paraneoplastic pemphigus (6,7) and Castleman disease.
Castleman disease is most often found in the mediastinum (67%) but has been identified in multiple anatomic locations, including the neck (14%), the pelvis (4%), and the axilla (2%).
Thoracic radiographic and CT findings of multicentric Castleman disease in HIV-infected patients.