Castleman disease

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Castleman disease

[kas´el-man]

a benign or premalignant condition resembling lymphoma but without recognizable malignant cells; there are isolated masses of lymphoid tissue and lymph node hyperplasia, usually in the abdominal or mediastinal area.

be·nign giant lymph node hy·per·pla·si·a

solitary masses of lymphoid tissue containing concentric perivascular aggregates of lymphocytes, occurring usually in the mediastinum or hilar region of young adults; similar changes have been reported outside the mediastinum and, if associated with interfollicular sheets of plasma cells, may progress to lymphoma or plasmacytoma.

Synonym(s): angiofollicular mediastinal lymph node hyperplasia, Castleman disease

Farlex Partner Medical Dictionary © Farlex 2012

Castleman disease

(kas′l-măn)

[Benjamin Castleman, U.S. pathologist, 1906–1982]

An occasionally aggressive illness marked by excessive growth of lymphoid tissue either localized in a single lymph node group or in multiple regions of the body. Although the cause is not precisely known, its associations with acquired immunodeficiency syndrome, Kaposi's sarcoma, and human herpes virus 8 infection have led some experts to propose that it has an infectious basis. Localized disease responds well to surgical resection. Widespread disease can sometimes be treated effectively with chemotherapy.

Castleman,

Benjamin, U.S. pathologist, 1906-1982.

Castleman disease - solitary masses of lymphoid tissue containing concentric perivascular aggregates of lymphocytes. Synonym(s): benign giant lymph node hyperplasia; Castleman tumor

Castleman tumor - Synonym(s): Castleman disease

Medical Eponyms © Farlex 2012

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References in periodicals archive ?

Update and new approaches in the treatment of Castleman disease. J Blood Med 2016; 7:145-158.

Mesentery root: a rare location of Castleman's disease

Presentation--Unicentric or localised Castleman disease is generally asymptomatic, but may cause the following symptoms.

A CASE REPORT OF CASTLEMAN DISEASE

Schutzner, "Myasthenia gravis, Castleman disease, pemphigus, and antiphospholipid syndrome," Muscle Nerve, vol.

A Case of Spondyloarthritis in Patient Affected by Unicentric Castleman's Disease Effectively Managed with Surgery Resection and Tocilizumab Treatment

Nabel et al., "Clinicopathologic analysis of TAFRO syndrome demonstrates a distinct subtype of HHV-8-negative multicentric Castleman disease," American Journal of Hematology, vol.

Anasarca, Fever, Thrombocytopenia, Organomegaly, and Multiorgan Failure in a 24-Year-Old Pregnant Woman

Aleman et al., "High-dose zidovudine plus valganciclovir for Kaposi sarcoma herpesvirusassociated multicentric Castleman disease: a pilot study of virus-activated cytotoxic therapy," Blood, vol.

Rituximab Monotherapy in the Management of a Rare Case of an HIV Associated Lymphoproliferative Disorder

As in our case, it exhibited features of Castleman disease in one case [3] and atrophic residual lymphoid follicles in another case [1].

HHV8/EBV Coinfection Lymphoproliferative Disorder: Rare Entity with a Favorable Outcome

19 Van Rhee F, Stone K, Szmania S, et al: Castleman disease in the 21st century: An update on diagnosis, assessment, and therapy.

CASTLEMAN'S DISEASE OF THE NECK - A CASE REPORT AND LITERATURE REVIEW

Paediatric Castleman disease: Report of seven cases and review of literature.

Castleman's disease imitating adrenal mass in the retroperitoneal area

HIV-associated multicentric Castleman disease. Curr Opin HIV AIDS 2009;4(1):16-21.

The diagnostic value of lymph node biopsy to detect Castleman's disease

Castleman disease in the neck: atypical appearance on CT.

49-year-old female with an anterior mediastinal mass

Multicentric Castleman disease and systemic lupus erythematosus phenotype in a boy with Klinefelter syndrome: long-term disease stabilization with interferon therapy.

Castleman's disease combined with the development of systemic lupus erythematosus: Sistemik Lupus Eritematoz Gelisimi ile Birlikte Seyreden Castleman Hastaligi

It has been implicated that HHV-8 may be associated with some human diseases including primary effusion lymphoma, a rare subtype of B-cell non-Hodgkin's lymphoma (NHL) [3], multicentric Castleman disease [4], angiosarcoma [5], angiolymphoid hyperplasia with eosinophilia [6], sarcoidosis [7], squamous cell carcinoma [8], pityriasis rosea [9], and multiple myeloma (MM) [10].