Castleman disease

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Castleman disease

a benign or premalignant condition resembling lymphoma but without recognizable malignant cells; there are isolated masses of lymphoid tissue and lymph node hyperplasia, usually in the abdominal or mediastinal area.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

be·nign giant lymph node hy·per·pla·si·a

solitary masses of lymphoid tissue containing concentric perivascular aggregates of lymphocytes, occurring usually in the mediastinum or hilar region of young adults; similar changes have been reported outside the mediastinum and, if associated with interfollicular sheets of plasma cells, may progress to lymphoma or plasmacytoma.
Farlex Partner Medical Dictionary © Farlex 2012

Castleman disease

[Benjamin Castleman, U.S. pathologist, 1906–1982]
An occasionally aggressive illness marked by excessive growth of lymphoid tissue either localized in a single lymph node group or in multiple regions of the body. Although the cause is not precisely known, its associations with acquired immunodeficiency syndrome, Kaposi's sarcoma, and human herpes virus 8 infection have led some experts to propose that it has an infectious basis. Localized disease responds well to surgical resection. Widespread disease can sometimes be treated effectively with chemotherapy.
Medical Dictionary, © 2009 Farlex and Partners


Benjamin, U.S. pathologist, 1906-1982.
Castleman disease - solitary masses of lymphoid tissue containing concentric perivascular aggregates of lymphocytes. Synonym(s): benign giant lymph node hyperplasia; Castleman tumor
Castleman tumor - Synonym(s): Castleman disease
Medical Eponyms © Farlex 2012
References in periodicals archive ?
Update and new approaches in the treatment of Castleman disease. J Blood Med 2016; 7:145-158.
Presentation--Unicentric or localised Castleman disease is generally asymptomatic, but may cause the following symptoms.
Schutzner, "Myasthenia gravis, Castleman disease, pemphigus, and antiphospholipid syndrome," Muscle Nerve, vol.
Nabel et al., "Clinicopathologic analysis of TAFRO syndrome demonstrates a distinct subtype of HHV-8-negative multicentric Castleman disease," American Journal of Hematology, vol.
Aleman et al., "High-dose zidovudine plus valganciclovir for Kaposi sarcoma herpesvirusassociated multicentric Castleman disease: a pilot study of virus-activated cytotoxic therapy," Blood, vol.
As in our case, it exhibited features of Castleman disease in one case [3] and atrophic residual lymphoid follicles in another case [1].
19 Van Rhee F, Stone K, Szmania S, et al: Castleman disease in the 21st century: An update on diagnosis, assessment, and therapy.
Paediatric Castleman disease: Report of seven cases and review of literature.
HIV-associated multicentric Castleman disease. Curr Opin HIV AIDS 2009;4(1):16-21.
Castleman disease in the neck: atypical appearance on CT.
Multicentric Castleman disease and systemic lupus erythematosus phenotype in a boy with Klinefelter syndrome: long-term disease stabilization with interferon therapy.
It has been implicated that HHV-8 may be associated with some human diseases including primary effusion lymphoma, a rare subtype of B-cell non-Hodgkin's lymphoma (NHL) [3], multicentric Castleman disease [4], angiosarcoma [5], angiolymphoid hyperplasia with eosinophilia [6], sarcoidosis [7], squamous cell carcinoma [8], pityriasis rosea [9], and multiple myeloma (MM) [10].