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a benign or premalignant condition resembling lymphoma but without recognizable malignant cells; there are isolated masses of lymphoid tissue and lymph node hyperplasia, usually in the abdominal or mediastinal area.
be·nign giant lymph node hy·per·pla·si·a
solitary masses of lymphoid tissue containing concentric perivascular aggregates of lymphocytes, occurring usually in the mediastinum or hilar region of young adults; similar changes have been reported outside the mediastinum and, if associated with interfollicular sheets of plasma cells, may progress to lymphoma or plasmacytoma.
[Benjamin Castleman, U.S. pathologist, 1906–1982]
An occasionally aggressive illness marked by excessive growth of lymphoid tissue either localized in a single lymph node group or in multiple regions of the body. Although the cause is not precisely known, its associations with acquired immunodeficiency syndrome, Kaposi's sarcoma, and human herpes virus 8 infection have led some experts to propose that it has an infectious basis. Localized disease responds well to surgical resection. Widespread disease can sometimes be treated effectively with chemotherapy.
Castleman,Benjamin, U.S. pathologist, 1906-1982.
Castleman disease - solitary masses of lymphoid tissue containing concentric perivascular aggregates of lymphocytes. Synonym(s): benign giant lymph node hyperplasia; Castleman tumor
Castleman tumor - Synonym(s): Castleman disease