In the plasma cell type of Castleman's Disease
, individuals may exhibit a variety of symptoms including fever, fatigue, excessive sweating, weight loss, skin rash, early destruction of RBCs leading to hemolytic anemia, and/or hypergammaglobulinemia.
Immunohistochemical evaluation revealed polyclonal cellular expansion consistent with the hyaline vascular variant of Castleman's disease
Pathogenic significance of interleukin-6 (IL-6/BSF-2) in Castleman's disease
. Blood 1989;74(4):1360-7.
presenting as a parotid mass in the pediatric population: a report of 2 cases.
(CD) is a rare lymphoproliferative syndrome typically involving a mediastinal mass.
Plasma cell variant represents less than 10% of Castleman's disease
and corresponds to 9% of the cases of localized Castleman's disease
Value of lymph node biopsy to detect Castleman's disease
After evaluating all of the data, the patient was diagnosed with Castleman's disease
(CD) and treated with five cycles of fludarabine 40 mg d1-d3 and cholera toxin (CTX) 0.4g d1-d3.
Intrathoracic multicentric Castleman's disease
: CT findings in 12 patients.
It also infects B lymphocytes and is associated with two B-cell lymphoproliferative diseases, primary effusion lymphoma  and multicentric Castleman's disease
New concepts have also materialised, such as the development of microlymphomas from Castleman's disease
into frank plasmablastic lymphomas.
In addition, there are reports of increased risk of several rare malignancies and proliferative lesions, including Merkel cell carcinoma, squamous cell carcinoma of the conjunctiva, and multicentric Castleman's disease
. As HAART becomes available in developing countries, the resulting longer life expectancy combined with the endemic viruses associated with cancer portend an increase in AIDS malignancies in these regions.