caspases


Also found in: Dictionary, Thesaurus, Encyclopedia.
Related to caspases: apoptosis, cytochrome c, Bcl-2

caspases

(kas'pās-ĕz),
Proteolytic cleavage products of the protein's procaspases that are responsible for cleaving and activation of additional procaspases into more caspases, thus resulting in a cascade of proteolytic activity the final result of which is apoptosis of the cell.
[cysteinyl aspartate specific proteinase]

caspases

A family of proteases, some of which are involved in APOPTOSIS.
References in periodicals archive ?
This closely regulated, energy-requiring process can be initiated through 2 different mechanisms, each based on the successive activation of preexisting but dormant cysteine-aspartate proteases, or caspases (Figure 1).
Wieckowska and her associates evaluated a caspase activity blood test in 44 consecutive patients with suspected NAFLD.
Studies of experimental allergic encephalomyelitis (EAE) in caspase 11-deficient mice show that caspasemediated death of OLGs is critical to demyelination.
Maxim's live-cell, high-throughput screening technology forms the basis for our caspase modulator program that is generating a rapidly growing portfolio of compounds," said Larry G.
Idun's lead compound, IDN-6556, a first-in-class pan caspase inhibitor, is
Idun's lead compound, IDN-6556, a first-in-class pan caspase inhibitor, is in Phase II clinical trials in liver transplantation and in patients infected with Hepatitis C virus.
Some studies strongly suggest that caspases play a key role in [Cd.
To calculate which protein is more likely to end up with the NO 'hot potato,' caspases or XIAP, the researchers created a new version of the Nernst equation - a 19th century mathematical equation taught in every general chemistry class.
We also demonstrated that these effects of rosamultic acid were mediated through cell cycle arrest, downregulation of cell cycle related protein expressions, inhibition of cell migration, DNA damage, and activation of caspases in these cells.
Furthermore, to confirm that this apoptosisinduction pathway is through caspase-9, a domant negative (DN) caspase-9 construct, which has been reported to inhibit the caspase cascade, was cotransfected wiwth pcWNV-Cp-DJY or pcWNV-CpWT and the expression level of procaspase-9 cleavage products (35-37 kDa) was compared to the activity of the 3'-deletion mutant, pcWNV-Cp[DELTA]3' and pcDNA3.
A new marker of apoptotic caspase activation in sera may provide a sensitive method for detecting patients with chronic hepatitis C virus infection who have significant liver fibrosis but have normal aminotransferase levels, reported Heike Bantel, M.