CASP1

(redirected from Caspase-1)

CASP1

A gene on chromosome 11q23 that encodes a protein belonging to the cysteine-aspartic acid protease (caspase) family which, once activated by proteolytic processing, plays a central role in the execution-phase of cell apoptosis, as well as various stages of embryological development.

Molecular pathology
CASP1 mutations may play a role in Huntington’s disease.
References in periodicals archive ?
AC-203 is a proprietary topical formulation of 1% diacerein, which has shown the ability to inhibit the production and activity of caspase-1 and the cytokine Interleukin-1Beta (IL-1Beta) through the inhibition of the assembly of the NLRP3 inflammasome.
The protein and RNA expression of IL-1[sz], IL-18, NLRP3, and caspase-1 in serum and muscle samples were tested and compared between the two groups.
By far, NLR protein 3 (NLRP3) inflammasome is the most extensively studied inflammasome, consisting of NLRP3, adaptor protein apoptosis associated speck-like protein (ASC) and serine protease caspase-1 precursor (procaspase-1) [2].
Upon activation, NLRP3 is ligated with ASC, which in turn combines procaspase-1, causing its transformation to cleaved caspase-1 that regulates the maturation of proinflammatory cytokines IL-1[beta] and IL-18 [15,16].
The mice were treated with the caspase-1 inhibitor, Ac-YVAD-CMK (10 mg/kg S.
Caspase-1 also controls the secretion of IL-1E-, but the mechanism and route of secretion are unknown.
This triggers the activation of the human enzyme caspase-1 and leads to pyroptosis, a fiery and highly inflammatory form of cell death.
Most published research suggested that caspase-11 was necessary only to activate caspase-1.
Caspases -2, -3, -6, and -9, but not caspase-1, are activated in sepsis-induced thymocyte apoptosis.
This assembly, the researchers explained, activates a powerful, protein-cleaving enzyme called caspase-1.
VX-765 is an oral medicine in development that is designed to inhibit Caspase-1, an enzyme involved in the production of IL-1 beta and linked to a wide range of immune and inflammatory responses.

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