caspase 9


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Related to caspase 9: Caspase 3, APAF3

caspase 9

A member of the CED-3 subfamily caspase-type protease activated by Apaf-1 binding, which is responsible for the proteolytic cleavage of many key proteins in apoptosis; caspase-9 plays a central role in cell death through an array of apoptosis inducers—e.g., TNF-alpha, TRAIL, anti-CD-95, FADD, TRADD4.
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References in periodicals archive ?
In contrast to T47D cell lines, MCF7 cell lines with tiliroside of 50 [micro]g/ml occurred weak expression of Caspase 8 (Figure 6) moreover Caspase 9 was not expressed.
These results have a similar profile for Caspase 9, in which tiliroside activates Caspase 9 and doxorubicin did not activate it.
This is through the release of Cytochrome c from mitochondria is a central event in the death receptor-independent, "intrinsic," apoptotic pathway which facilitates activation by Caspase 9 of the effector Caspases [1], which subsequently activates Caspase 3, and ultimately leads to the apoptotic cell death.
8 and Caspase 9 colorimetric assay: R&D Systems, Inc.
(California, USA) were used consisting of [beta]-Actin (1:1000), Bax (1:1000), Bcl2 (1:1000), Hsp70 (1:1000), survivin (1:1000), caspase 3 (1:1000) and caspase 9 (1:1000).
Initiating caspase 9 plays a role in the intrinsic pathway of the apoptosis, but in the extrinsic pathway the key role is played by the death receptor and by caspase 8 [41-43].
Methods: The cytotoxicity of the compounds was determined using a resazurin reduction assay, whereas the caspase-Glo assay was used to detect the activation of caspases 3/7, caspase 8 and caspase 9 in cells treated with compounds 3.
Effect of GS-Rb1 on the Activation of Caspase 3 and Caspase 9. Activation of caspase-3 and caspase-9 is a key irreversible point in mitochondria mediated apoptosis.
Compounds 2-4 strongly induced apoptosis in CCRF-CEM cells via caspases 3/7, caspase 8 and caspase 9 activation and disruption of MMP.
Effect of becatamide on caspase 9 activity in [H.sub.2][O.sub.2]-treated PC12 cells

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