caspase 3

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caspase 3

A 32-kD cysteine-aspartic acid protease encoded by CASP3 on chromosome 4q34, which is related to ICE–IL-1 beta converting enzyme, and plays a key role in the execution-phase of apoptosis via poly-(ADP)-ribose-polymerase cleavage. Caspase 3 cleaves and activates caspases 6, 7 and 9, and is itself processed by caspases 8, 9 and 10. It is the key caspase in cleaving amyloid-beta 4A precursor protein, which is linked to neuronal death in Alzheimer's disease.

Normal expression
Caspase 3 is expressed on germinal centre B cells, plasma cells, and on scattered activated B cells.

Abnormal expression
Some non-Hodgkin lymphomas.
References in periodicals archive ?
Objective: To determine the applicability of urinary caspase 3 enzyme and TNF-a as biomarkers in children with ureteropelvic junction obstruction (UPJO).
MCF-7 cancer cell lines are characterized by resistance chemotherapeutic agents, [17,18] responsive estrogen receptors (ER+), overexpression of Bcl-2, [19,20] and with no expression of Caspase 3.
These findings are in accordance with [20] who found that the beta- carotene blocked the mitochondrial permeability transition (MPT) and decreased the activation of Caspase 3.
Improved detection of apoptotic cells in archival paraffin sections: Immunohistochemistry using antibodies to cleaved caspase 3.
Activation of P53 death signals lead to Caspases activation and thus can induce apoptosis through release of mitochondrial Cytochrome c into the cytoplasm which then facilitates activation of Caspase 9, leading to activation of Caspase 3 and other effector caspases.
Cell death was further validated through the mRNA and protein overexpression of Bax, caspase 3 and caspase 9 in the treated cells compared with the untreated cells.
Su, "Tanshinone IIA inhibits human hepatocellular carcinoma J5 cell growth by increasing Bax and caspase 3 and decreasing CD31 expression in vivo," Molecular Medicine Reports, vol.
Caspase activity was determined on the basis of transformed ability of caspase 3, 8 and 9 (Beyotime, China).
The "Mos-iCsp3" mouse (for "mosaic inducible caspase 3 mouse") is engineered so that administration of a drug initiates destruction of cells in specifically designated tissues, explains Dr.
The altered expression of Bcl-2 family member proteins triggered the release of cytochrome-C and activation of initiator capsase 9 followed by activation of effector caspase 3.
pallida is homologous in deduced amino acid sequence and secondary structure to vertebrate executioner caspase 3 (Dunn et al.
Caspase 1 and caspase 3 inhibition protects OLGs against TNF-[alpha]-induced apoptosis [38-41].

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