CASP12

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CASP12

A pseudogene on chromosome 11q22.3 that encodes a protein which lacks protease activity. CASP12 may reduce cytokine release in response to bacterial lipopolysaccharide during infection and downregulate activation of NF-kappa-B in response to TNF.
References in periodicals archive ?
In mice, caspase 12 appears to be localized to endoplasmic reticulum (ER), and is activated in response to stimuli by which ER became stressed and release the calcium stored (Nakagawa et al.
This novel observation associated with the benzene toxicity mechanism together with the downmodulation of caspase 12 was similarly addressed using WT and p53-KO mice in the study of the mechanism of chronic obstructive urinary disturbances (Choi et al.
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