CASP8

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CASP8

A gene on chromosome 2q33-q34 that encodes a protein belonging to the cysteine-aspartic acid protease (caspase) family which, once activated by proteolytic processing, plays a central role in the execution phase of cell apoptosis, as well as various stages of embryological development. CASP8 is an initiator-type caspase, which is activated by, and interacts with, upstream adaptor molecules through CARD and DED protein–protein interaction domains; it is involved in the programmed cell death induced by Fas and various apoptotic stimuli. It is highly expressed in peripheral blood leukocytes and in the spleen, thymus and liver.

Molecular pathology
CASP8 has been detected in the insoluble fraction of affected brain regions in Huntington disease, suggesting a role in neurodegenerative diseases.
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References in periodicals archive ?
CCNDI, CDK6, p21, p53, Caspase-3 (CASP-3), Caspase-8 (CASP-8, Caspase-9 (CASP9), BCL-2, Ataxia Telangiectasia Mutated (ATM), Ataxia Telangiectasia and Rad-3 Related (ATP), BAX, Checkpoint kinase 1-2 (CHEK1, CHEK2) and Excision repair cross-complementing I (EPCCI) gene expression analyses were performed using the StepOnePlus quantitative RTPCR system (Applied-Biosystems, USA) with respect to SYBR Green (Thermo-Scientific, USA) method.
We determined that ISO has an effect on protease activities of CASP-3 and CASP-8. There was a significant increase in CASP-3 and CASP-8 activation in ISO-treated HT-29 cells compared with that in control group cells (p<0.05; Table I).
Therefore, ISO-induced apoptosis is caspase dependent, and ISO significantly increases expression levels of CASP-3 and CASP-8 in colorectal adenocarcinoma cells compared with those in the control group cells.