The third phase of the experiment consisted of administration of Carum carvi extract to the same groups of animals after having recovered completely to normal condition.
The final phase of the experiment consisted of studying the influence of Carum carvi extract on stress induced changes in the same groups of animals after a recovery period of one week.
The nootropic activity of Carum carvi was evaluated by using the conditioned avoidance response (CAR) in rats as described by Cook & Weidley (1957).
The antioxidant activity of Carum carvi was determined based on its ability to inhibit lipid peroxidation in homogenates of the liver and brain of rats (Okhawa 1979).
Daily treatment of Carum carvi to the animals under normal condition produced no change in the excretion of VMA and ascorbic acid compared with normal basal levels indicating that Carum carvi did not alter excretion of VMA and ascorbic acid in normal condition.