Cartilage-cell culturing service Orthopedics A technique in which a Pt's own cartilage cells are removed, grown, reimplanted to fill a cartilage defect of the knee and, at the surgeon's discretion, glued with fibrin glue for watertightness. See Cell culture.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
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Carticel from Sanofi's (SNY) Genzyme unit and MACI from Vericel (VCEL) have received FDA approval for the culturing of chondrocytes through a biologics license for specific indications.
ICT will acquire exclusive rights to develop and distribute Carticel, MACI, Ixmyelocel-T, and Epicel in China, South Korea, Singapore, and other countries in the region.
ICT will acquire exclusive rights to develop and distribute Carticel , MACI , Ixmyelocel-T, and Epicel in China, South Korea, Singapore, and other countries in the region.
Total revenues of USD10.8m were collected for the quarter ended 31 March 2015 and included approximately USD7.1m in net sales of Carticel implants and surgical kits and USD3.6m in net sales of Epicel.
According to Nick Colangelo, Aastrom's president and chief executive officer, the new corporate name reflects its leading position in the cell therapy market and its expanded presence in the vibrant Cambridge biotechnology community will increase its access to both talent and technology, maximise the potential of its two US marketed products, Carticel and Epicel and bring its late-stage product candidates, MACI and ixmyelocel-T, to market.
There are regenerative medicines used to regenerate tissue, with products such as Organogenesis' Dermagraft and Apligraf, and Aastrom's Carticel and TiGenix's ChondroCelect, which regenerate and replace cartilage.
The earliest example of this type of "product" is the autologous cultured cartilage process marketed by Genzyme as Carticel. In this process the surgeon takes a cartilage biopsy and sends this to a central Genzyme lab where it cultured for several months.
The company also reports that findings from a large, multicenter, observational study on long-term durability of Carticel (autologous cultured chondrocytes) in patients who had pain and functional defects in the articular cartilage in their knees were positive.
said Monday that patients who had poor results from cartilage repair procedures showed sustained improvement with Carticel, a cartilage replacement surgically implanted in the knees.
Carticel (autologous cultured chondrocytes), Genzyme's first-generation product, has been used in more than 10,000 patients since it was introduced in 1995.
Additional products of this sort include Vitrix, which is meant to help deep wounds heal without scarring and Carticel, a man-made cartilage harvested in a plastic biodegradable matrix.
Genzyme Biosurgery reported that the topics covered included "the five-year results of the first 100 patients treated with Carticel to repair damaged cartilage on the thigh bone part of the knee; the potential of Carticel in treating injuries to the trochlea, a specific area of the femur beneath the knee cap; and the results of Carticel compared with so-called marrow stimulation techniques, an alternative treatment for some cartilage injuries."