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Related to carisoprodol: cyclobenzaprine, Tramadol


an analgesic and skeletal muscle relaxant used to relieve symptoms of acute painful skeletomuscular disorders, administered orally.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.



Pharmacologic class: Carbamate derivative

Therapeutic class: Centrally acting skeletal muscle relaxant

Controlled substance schedule IV (in some states)

Pregnancy risk category C


Unknown. May modify central perception of pain without modifying pain reflexes. Skeletal muscle relaxation may result from sedative properties or from inhibition of activity in descending reticular formation and spinal cord.


Tablets: 250 mg, 350 mg

Indications and dosages

Adjunctive treatment of muscle spasms associated with acute painful musculoskeletal conditions

Adults: 350 mg P.O. q.i.d.

Relief of discomfort associated with acute painful musculoskeletal conditions

Adults: 250 to 350 mg P.O. t.i.d. and at bedtime


• Hypersensitivity to drug or meprobamate

• Porphyria or suspected porphyria


Use cautiously in:

• severe hepatic or renal disease

• history of substance abuse

• pregnant or breastfeeding patients

• children ages 12 and younger.


• Give last daily dose at bedtime.

• Administer with food if GI upset occurs.

• If patient can't swallow tablets, mix with syrup, chocolate, or jelly.

Adverse reactions

CNS: dizziness, drowsiness, agitation, ataxia, depression, headache, insomnia, vertigo, tremor, depression

CV: hypotension, tachycardia

GI: nausea, vomiting, epigastric distress

Hematologic: eosinophilia, leukopenia

Respiratory: asthma attacks

Skin: flushing (especially of face), rash, pruritus, erythema multiforme

Other: hiccups, fever, psychological drug dependence, anaphylactic shock


Drug-drug. Antihistamines, opioids, sedative-hypnotics: additive CNS depression

Drug-diagnostic tests. Eosinophils: increased count

Drug-herbs. Chamomile, hops, kava, skullcap, valerian: increased CNS depression

Drug-behaviors. Alcohol use: increased CNS depression

Patient monitoring

• When giving to breastfeeding patient, watch for signs of sedation and GI upset in infant.

• Monitor range of motion, stiffness, and discomfort level.

• Know that drug is metabolized to meprobamate. Monitor for drug dependence, especially in patients with history of substance abuse.

Patient teaching

• Tell patient that psychological drug dependence may occur.

• Instruct patient to avoid over-the-counter drugs and alcohol, because they may increase CNS depression.

• Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration and alertness.

• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, tests, herbs, and behaviors mentioned above.

McGraw-Hill Nurse's Drug Handbook, 7th Ed. Copyright © 2013 by The McGraw-Hill Companies, Inc. All rights reserved


Rela® Pharmacology A muscle relaxant related to meprobamate. See Meprobamate.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.


A centrally-acting muscle relaxant drug used in the treatment of muscle spasms. A brand name is Carisoma.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
References in periodicals archive ?
De acordo com a metodologia utilizada pode-se concluir que os AINE constituem-se em farmacos com alta dispensacao em farmacias magistrais, sendo em sua maior parte associados a outros AINE e a outras classes de medicamentos; o AINE mais dispensado e o paracetamol, seguido do naproxeno, nimesulida, diclofenaco de sodio e diacereina; dentre as associacoes mais comuns na farmacia magistral destaca-se a associacao de paracetamol + meloxicam + ranitidina + carisoprodol; os bloqueadores de H2 sao os farmacos mais associado aos AINE; as associacoes prescritas para a farmacia magistral nao sao disponibilizadas na industria farmaceutica; a maioria dos AINE dispensados na manipulacao foi atraves de prescricao medica; o principio ativo mais dispensado sem prescricao foi o paracetamol.
According to IMS Health data, the US market sales for Carisoprodol and Aspirin Tablets (USP) and Sodium Bicarbonate Tablets (USP) were about USD3.1m collectively for the 12 month period ending 31 December 2011.
The AS (Ashworth, 1964) was originally developed to assess responsiveness to treatment of spasticity to treatment with carisoprodol in multiple sclerosis.
Contributors working in brain research, psychology, public health, psychiatry, cardiology, and other medical fields in Europe, Africa, the US, and Japan discuss the use of psychotropic analgesic nitrous oxide for alcohol withdrawal; withdrawal from SSRIs, benzodiazepine, carisoprodol, caffeine, cocaine, and alcohol; and the impact of aspirin withdrawal in patients with coronary artery disease.
The drugs covered in this edition include general anaesthetic agents (inhalational and intravenous), local anaesthetics, neuromuscular blocking drugs and a somewhat bizarre collection of muscle relaxants (including baclofen, botulinum toxins, carisoprodol, chlormezanone, dantrolene and some others).
* Muscle relaxants (carisoprodol, chlorzoxazone, cyclobenzaprine, methocarbamol, metaxalone, oxybutynin)
Investigators for the MHRA visiting the company had discovered Sildenafil and Tadalafil, both used to treat erectile dysfunction, Carisoprodol, used as a muscle relaxant, and Sibutramine Hydrochloride, used to treat obesity, the agency said.
The contents were unlicensed medicines in the form of sildenafil and tadalafil (both used to treat erectile dysfunction), carisoprodol (used as a muscle relaxant) and sibutramine hydrochloride (used to treat obesity).
Commonly used muscle relaxant therapies for acute low back pain: a review of carisoprodol, cy-clobenzaprine hydrochloride, and metaxalone.
Also missing were 415 Carisoprodol pills, 33 Robaxin, 79 Topomax/Klonopin and 24 diuretics/antibiotics - although it is not clear whether she had downed them all.