HEY1

(redirected from Cardiovascular helix-loop-helix factor 2)

HEY1

A gene on chromosome 8q21 that encodes a DNA-binding basic helix-loop-helix (bHLH) transcription factor. HEY1 is a downstream effector of Notch signalling and may be required for cardiovascular development by downregulating the cardiac transcriptional activators GATA4 and GATA6. It is expressed in the mesoderm, CNS, kidneys, heart, nasal epithelium and limbs, and it interacts with HES1, HEYL, HDAC1, NCOR1, SIN3A, GATA4, GATA6 and CCDC89/BOIP.
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