Cardiovascular Endpoint

An objective morbid condition or cause of death linked to cardiovascular disease, used as an indicator in a clinical trial or reportable event
Examples Cardiovascular death, nonfatal myocardial infarction, hospitalization for heart failure, increase in blood pressure, etc.
References in periodicals archive ?
After the primary composite cardiovascular endpoint was assessed, the trial continued as an observational study, with all patients given the intensified, multifactorial treatment that consisted of lifestyle measures and medications targeting hyperglycemia, hypertension, hypercholesterolemia, and hypercoagulation.
However, patients with a plasma troponin of 5 ng/L or greater recorded at either the baseline or 3-month assessment had an increased rate of the composite cardiovascular endpoint and a "markedly increased" risk of cardiovascular death, they wrote.
After the primary composite cardiovascular endpoint was assessed in the 160 high-risk patients enrolled, the trial continued as an observational study, with all patients given the intensified, multifactorial treatment comprising lifestyle measures and medications targeting hyperglycemia, hypertension, hypercholesterolemia, and hypercoagulation.
Two DAD Study analyses, (2,20) a EuroSIDA review, (1) the SMART cardiovascular endpoint dissection, (3) and a combined analysis of the ESPRIT and SILCAAT interleukin 2 (IL-2) trials (37) discerned no link between CD4 count (measured various ways) and risk of cardiovascular disease (also measured various ways) (Table 1).
Nonetheless, the Veterans Affairs High-Density Lipoprotein Cholesterol Intervention Trial Study Group reported a benefit of gemfibrozil on coronary heart disease without a significant change in LDL-C (19), and the Helsinki Heart Study showed a benefit of gemfibrozil in the subgroup with a high LDL-C/HDL-C ratio and a high triglyceride concentration (20).More recently, the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) trial failed to significantly reduce the primary cardiovascular endpoint despite a 29% difference in triglyceride concentrations between fenofibrate and placebo, as well as a 12% difference in LDL-C concentration and a 5% difference in HDL-C concentration (21).
* The independent safety monitoring board for the RECORD trial--a large, long-term clinical trial, which has been designed to look at cardiovascular outcomes in people with diabetes--reviewed an interim analysis of cardiovascular endpoint in all study participants, and determined that the study should be allowed to continue.
No apparent association was observed between consumption of tea and the risk of cardiovascular endpoint; however, only 664 men drank four or more cups of tea per day."
But large, well-designed, randomized controlled trials of intensive blood pressure lowering in people with diabetes, such as ACCORD-BP, did not demonstrate that intensive blood pressure lowering targeting a systolic less than 120 mm Hg had a significant benefit on the composite primary cardiovascular endpoint. And while the ADVANCE BP trial found that the composite endpoint was improved with intensive blood pressure lowering, the blood pressure level achieved in the intervention group was 136/73 mm Hg.
During the 76-week treatment phase, the pre-specified adjudicated cardiovascular endpoint occurred in 16 anacetrapib-treated patients compared with 21 placebo-treated patients.
Major finding: The hazard ratio for the primary composite cardiovascular endpoint with celecoxib use was 1.12 (95% confidence interval, 0.81-1.55; P = .5), compared with NSAIDs.
"EMPA-REG OUTCOME was the first diabetes outcome trial to show a reduction in the primary cardiovascular endpoint," Dr.
Major finding: Sitagliptin was found noninferior to placebo for a combined cardiovascular endpoint comprising first time to CV death, nonfatal myocardial infarction, or stroke; and hospitalization for unstable angina (HR, 0.98; 95% CI, 0.88-1.09; P less than .001).
Full browser ?