Hence, studies were conducted on the mechanism of the
cardiotoxic side effects of local anaesthetics and research for drugs with less
cardiotoxic profile is continuing.
First-line treatments are sertraline and citalopram; among contraindicated treatments are tricyclic antidepressants and monamine oxidase inhibitors, which have
cardiotoxic side effects, the advisory states.
Radiation and anthracyclines are directly
cardiotoxic, while the VEGF inhibitors appear to frequently cause hypertension.
The guidelines recommend cardiac tests for patients undergoing chemotherapy with known
cardiotoxic agents, discuss the cardiac problems linked to radiation treatment, and suggest which cardiac tests are useful for patients who underwent previous radiation to the chest and now need chemotherapy.
The
cardiotoxic interaction between trastuzumab and anthracycline also came to the fore in terms of an increased incidence of severe chronic heart failure, as noted in other studies.
The persistence of increased concentrations for more than 72 h suggests that in these patients the increase in NT-proBNP reflects the presence of an underlying reduced functional myocardial reserve or reduced cardiac tolerance to
cardiotoxic agents.
"In contrast with cocaine, long-term methamphetamine use seems to have a direct,
cardiotoxic effect, and promotes the development of severe, nonischemic, dilated cardiomyopathy," according to Dr.
[5] Its congener levobupivacaine is less
cardiotoxic and is frequently being used now-a-days.
Women who do use cocaine, however, are much more likely than men to experience
cardiotoxic effects.
For nearly three decades, reports have appeared that describe the fatal
cardiotoxic effects of this drug (6-8).
The levorotatory isomers were shown to have a safer pharmacological profile with less
cardiotoxic and neurotoxic effects and it is attributed to its faster protein binding rate.
But they worried about possible
cardiotoxic effects of exogenous testosterone in a vulnerable HF population.
