More patients are living long enough to experience this risk of cardiac toxicity
. We need to start paying attention to this and working together with cardiologists to help these patients," Mak added.
Another drug with a similar action, the minoxidil, was suspected to be associated with pericardial effusion, that may be explain the cardiac toxicity
of the drug (5).
However, neither could explain her presentation especially with negative paracetamol levels and the presence of significant cardiac toxicity
. The combination of CNS depression with refractory arrhythmias made hydrocarbon toxicity likely.
Co-lead author Dr Lisa Scudder said: "One of the major challenges in drug discovery and development is failure at the clinical testing stage due to cardiac toxicity
. A way to overcome this is to develop new preclinical tests for new drugs using engineered tissues that mimic the native organs of the human body such as the heart."
5-FU has been found to be an agent that may cause direct reversible cardiac toxicity
or exacerbate the cause of myocardial dysfunction.
Older patients appear to be more prone to cardiac toxicity
especially when trastuzumab is used [18,20].
The therapeutic effects of thymoquinone in blood serum markers of cardiac toxicity
such as AST, ALT, LDH, and CK-MB levels are summarized in Table 1.
has been a major contributing factor, and conventional non-human cell and animal models are part of the problem: they are poorly predictive of human responses, leading to false negative and false positive results that compromise overall successes.
It is known to significantly reduce the rate of breast cancer recurrence, but it has been linked to cardiac toxicity
, particularly when used in conjunction with anthracycline chemotherapy (not in our patient) (2).
As a result, AP drugs, in addition to direct cardiac toxicity
, can cause a prolongation of the QTc interval by dis-metabolism and NAFLD (21).
In addition, cardiac toxicity
was less with the short HER regimen.