In lieu of flowers, donations may be made in memory of John Lazar to fund Cardiac Amyloidosis
Research on behalf of Dr.
Deposition of mutant TTR in the heart may lead to cardiac amyloidosis
Alnylam reported that the Phase II trial is aimed at evaluating the tolerability and preliminary clinical activity of ALN-TTRsc in TTR cardiac amyloidosis
patients with familial amyloidotic cardiomyopathy (FAC) - which is caused by autosomal dominant mutations in the TTR gene, or senile systemic amyloidosis (SSA) - which is caused by idiopathic accumulation of wild-type TTR in the heart.
Also, within the "senile" amyloidosis category, involvement may be systemic or isolated to the heart, and two distinct subtypes of senile cardiac amyloidosis
have been described.
Tissue Doppler imaging in the evaluation of patients with cardiac amyloidosis
It has also been used to evaluate the right ventricular function in various pulmonary disease such as pulmonary hypertension (PHT), chronic pulmonary disease (CPD) and cardiac amyloidosis
(9, 11, 12).
Cardiovascular involvement in rheumatoid arthritis (RA) is a rare extra-articular finding; however, pericarditis, cardiomyopathy/myocarditis, cardiac amyloidosis
, coronary vasculitis, arrhythmia, valvular disorders, congestive heart failure, and ischemic heart disease may be seen in RA.
Comparison of magnetic resonance imaging versus Doppler echocardiography for the evaluation of left ventricular diastolic function in patients with cardiac amyloidosis
, a monoclonal gammopathy and a potentially misleading mutation.
In a series of 50 consecutive patients with light-chain amyloidosis and 15 patients with hereditary amyloidosis, cTnT values in patients with cardiac amyloidosis
were increased compared to those in patients with light chain amyloidosis but no cardiac involvement [0.
2) Endomyocardial biopsy, though invasiye, is indicated in patients with suspected cardiac amyloidosis
and unexplained diastolic heart failure, especially when extracardiac tissue is negative for amyloid.
Lewis had a rare condition called cardiac amyloidosis
, a disease in which the heart is infiltrated by an abnormal protein produced elsewhere in the body.