Cardiac Arrhythmia Suppression Trial


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Cardiac Arrhythmia Suppression Trial

See CAST, CAST-2.
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9] The Cardiac Arrhythmia Suppression Trial (CAST) Investigators, "Preliminary report: effect of encainide and flecainide on mortality in a randomized trial of arrhythmia suppression after myocardial infarction," The New England Journal of Medicine, vol.
Begun in June 1987 and designed to run until 1992, the Cardiac Arrhythmia Suppression Trial sought to compare each of the three drugs to placebo in a total of 4,400 patients who had a heart attack and developed arrhythmias within two years before enrollment in the study.
The Cardiac Arrhythmia Suppression Trial (CAST) and clarithromycin are mentioned in appropriate chapters, for example.
A recent example is the Cardiac Arrhythmia Suppression Trial (CAST) study results, which revealed an increased mortality associated with suppression of ventricular arrhythmias in survivors of myocardial infarction.
Both Cardiac Arrhythmia Suppression Trials (CAST I: encainide and flecainide; CAST II: moricizine) showed that suppressing frequent PVCs significantly increased mortality in the treatment groups.

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