CES1

(redirected from Carboxylesterase 1)
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CES1

A gene on chromosome 16q22.2 that encodes a member of the carboxylesterase family, which hydrolyse or transesterify xenobiotics (e.g., cocaine and heroin) and endogenous substrates with ester,
thioester or amide bonds. CES1 may participate in fatty acyl and cholesterol ester metabolism, and may play a role in maintaining the blood-brain barrier. It is the major liver enzyme and functions in liver drug clearance.
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[4] Human genes: APOE, apolipoprotein E; SLCO1B1, solute carrier organic anion transporter family member 1B1; LPA, lipoprotein(a); SORTI, sortilin 1; ABCB1, ATP binding cassette subfamily B member 1; ABCG2, ATP binding cassette subfamily G member 2; HMGCR, 3-hydroxy-3-methylglutaryl-CoA reductase; CELSR2, cadherin EGF LAG sevenpass G-type receptor 2; PSRC1, proline and serine rich coiled-coil 1; KIF6, kinesin family member 6; CYP2C19, cytochrome P450 family 2 subfamily C member 19; P2RY12, purinergic receptor; CYP2C9, cytochrome P450 family 2 subfamily C member 9; CES1, carboxylesterase 1; UGT2B7, UDP glucuronosyltransferase family 2 member B7; VKORC1, vitamin K epoxide reductase complex subunit 1.
INHIBITION POTENCY OF ORGANOPHOSPHATES ON HUMAN CARBOXYLESTERASE 1 PROTEIN Katye Herring, Abdolsamad Borazjani, Allen Crow, Matt Ross Mississippi State University
Although both accession number X81395 and accession number U10697 were annotated as carboxylesterase 1 (Ces1) (presumably because of DNA sequence homology), the amino acid sequences are divergent enough to suggest that these are indeed two different proteins (data not shown).