The PCR product of DNA encoding the carboxyl terminal
PROLOR's CTP technology is based on a short amino acid sequence, the Carboxyl Terminal
Peptide that occurs naturally in humans.
HMG-CoA reductase is anchored in the membrane of the endoplasmic reticulum, and was long regarded as having seven transmembrane domains, with the active site located in a long carboxyl terminal
domain in the cytosol (9).
1] cells expressed an approximate 70-kDa band that was immunoreactive to a rabbit antibody directed to the intracellular carboxyl terminal
domain, unique to the P2X7 class of purinergic receptors (Figure 8).
Another important conserved feature identified through sequence analyses is the carboxyl terminal
domain of approximately 20 amino acids.
These results lead us to hypothesize that the PEST motif in squid myosin V is located about the same distance away from the carboxyl terminal
in the squid myosin V as in chick myosin V.