carbonic anhydrase

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anhydrase

 [an-hi´drās]
an enzyme that catalyzes the removal of water from a compound.
carbonic anhydrase an enzyme that catalyzes the decomposition of carbonic acid into carbon dioxide and water, facilitating transfer of carbon dioxide from tissues to blood and from blood to alveolar air.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

car·bon·ic an·hy·drase

a zinc-containing enzyme that catalyzes the interconversion of CO2 with HCO3- and H+. There are at least seven human isozymes that appear predominantly in red blood cells, secretory tissues, and muscle. A deficiency of carbonic anhydrase II can result in osteopetrosis and metabolic acidosis. The inhibition of carbonic anhydrase IV and possibly carbonic anhydrase II by sulfonamides is a current therapy in the treatment of glaucoma.
Farlex Partner Medical Dictionary © Farlex 2012

carbonic anhydrase

an enzyme that accelerates the reaction between carbon dioxide and water to form carbonic acid in the red blood cells.
Collins Dictionary of Biology, 3rd ed. © W. G. Hale, V. A. Saunders, J. P. Margham 2005
References in periodicals archive ?
Budayova-Spano et al., "Atomic crystal and molecular dynamics simulation structures of human carbonic anhydrase II: insights into the proton transfer mechanism," Biochemistry, vol.
Autoantibodies against carbonic anhydrase II are increased in renal tubular acidosis associated with Sjogren syndrome.
Developmental regulation of glutamine synthetase and carbonic anhydrase II in neural retina.
This is the first study to demonstrate that carbonic anhydrase II (CA II) may be linked to human aspirin resistance (AR).
Renal tubular acidosis and osteopetrosis with carbonic anhydrase II deficiency: pathogenesis of impaired acidification.
Moreover, genes regulating bone resorption of osteoclasts (Cathepsin K, MMP-9, Carbonic Anhydrase II, and TRAP [30, 31]) were reduced when they were cocultured with PTL-treated hPDLCs.
During bone resorption by osteoclast, carbonic anhydrase II, which is localized in the cytoplasm of osteoclasts, produces protons from [H.sub.2]C[O.sub.3]; these protons are secreted into the resorptive cavity through apical [H.sup.+]/ATPase [3].
Type III RTA is usually the result of an inherited carbonic anhydrase II mutation, and it gives rise to an autosomal-recessive syndrome of metabolic acidosis, hypokalemia, osteoporosis, cerebral calcification, and mental retardation.
ARO can result from mutations in the TCIRG1 gene (T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein a isoform 3) (3) the CLCN7 gene (chloride channel 7) (4) the OSTM1 gene (osteopetrosis-associated transmembrane protein 1) (5) the TNFSF11 gene (tumour necrosis factor ligand superfamily, member 11 encoding receptor activator for nuclear factor kappa b ligand, RANKL) (6), the TNFRSF11A gene (tumour necrosis factor ligand superfamily, member 11A encoding receptor activator of nuclear factor-kappa B, RANK) (7) or PLEKHM1 gene (pleckstrin homology domain-containing protein, family M, member) (8) and CA2 gene (carbonic anhydrase II) (9).
Induction of experimental autoimmune sialoadenitis by immunization of PL/J mice with carbonic anhydrase II. J Immunol 1995;154:4865-73.
Since then, others have reported meeting some or all of these criteria.[6-8] Kino-Ohsaki et al[9] proposed that antibodies to carbonic anhydrase II antigens, present on the epithelial cells of eccrine ducts, might be responsible for the antibody-mediated reaction that causes the lymphoplasmacytic infiltration of the main pancreatic ducts in patients presenting with idiopathic pancreatitis and Sjogren's syndrome.
Liljas, "Refined structure of human carbonic anhydrase II at 2.0 A resolution," Proteins: Structure, Function, and Genetics, vol.

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