Inhibition of neuroinflammation and mitochondrial dysfunctions by carbenoxolone
in the rotenone model of Parkinson's disease.
2,599 items of experiments involved in drug testing protocols ((2R)-amino-5-phosphonovaleric acid (APV), bicuculline (BIC), 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX), tetrodotoxin (TTX), octanol (OCT), carbenoxolone
(CBX), brain-derived neurotrophic factor (BDNF), etc.).
, a hemi-succinate ester of glycyrrhizic acid which has been synthetically produced from liquorice, also has this action.
This ATP release was Panx1 channel-mediated as shown by the prevention of ATP release with pharmacological inhibitors, such as carbenoxolone
(CBX) or  Panx, and with siRNA-mediated knockdown of Panx1.
Several HSF-1 modulators including celastrol and carbenoxolone
can trigger HSF-1 activation, leading to downstream induction of Hsp70 expression  (Figure 1).
The mice were divided into different groups (n = 6) and pretreated orally with vehicle (water, 10mL/kg), carbenoxolone
(used as the positive control, 100mg/kg), MEMN (30-300mg/kg), or MERN (10-300 mg/kg); an ulcerogenic solution composed of 60% ethanol/0.3M HCl was orally given to the mice one hour after the pretreatments .
(CBX) is a synthetic GL derivative that abrogated lipopolysaccharide- (LPS-) induced HMGB1 release in macrophage cultures by impairing PKR activation .
Effects of carbenoxolone
in lean and obese Zucker rats," Journal of Pharmacology and Experimental Therapeutics, vol.
In order to measure the effect of gap junction blockers on [H.sub.2][O.sub.2]-induced cell death, gap junction Cx43 blocker carbenoxolone
(Cbx) at the concentration of 100 [micro]M was added 30 min earlier before [H.sub.2][O.sub.2] treatment.
Mucosal changes in gastric ulceration and their response to carbenoxolone
and triterpenoids inhibited mucin secretion from airway epithelial cells.
W., Colin Jones D.G., Mucosal changes in gastric ulceration and their response to carbenoxolone