carbapenems


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car·ba·pen·ems

(kar-bă-pen'emz),
A class of broad-spectrum bactericidal β-lactam antibiotics (for example, imipenem) that bind to penicillin-binding protein 2 and thereby interfere with cell wall structure; they are highly resistant to β-lactamases and easily penetrate bacterial walls.

carbapenems

A range of antibiotic drugs that are derivatives of thienamycin produced from Streptomyces cattleya . The carbapenems act by inhibiting the synthesis of the bacterial wall and are bactericidal. They have a broad spectrum of action against both Gram-positive and Gram-negative organisms.

car·ba·pen·ems

(kahrbă-penemz)
Broad-spectrum bactericidal β-lactam antibiotics that bind to penicillin-binding protein and thereby interfere with cell wall structure.
References in periodicals archive ?
Amplification of blaNDM-1 producers: Plasmid DNA was extracted for selected phenotypically carbapenems resistant isolates using GeneJET Plasmid Miniprep Kit by Thermo Fisher Scientific Lithuania, according to the manufacturer's instructions.
Isolates showing resistance to carbapenems (Imipenem 10ug) were screened for presence of MBL by the IMP-EDTA double disk-diffusion test (DDDT).
In our study, Colistin and Polymyxin-B antibiotics had 100% sensitivity followed by carbapenems (86%), Amikacin (74.4%), Moxifloxacin (69.8%), levofloxacin (62.8%), Ciprofloxacin (62.8%), Piperacillin-tazobactam (62.8%) and the least was in Azithromycin (32.6%).
There are currently few antibiotics to combat bacteria that are resistant to Carbapenems - still a last-resort antibiotic class - and worldwide spread of blaNDM-1 and related ARGs is a concern.
Instead, Azithromycin should be used to treat patients with suspected uncomplicated typhoid fever and carbapenems for patients with suspected severe or complicated typhoid fever.
However, there was no difference between the three combinations with tigecycline, carbapenems, and amikacin.
Isolates found to show reduced susceptibility to the carbapenems as per antibiotic breakpoints recommended by CLSI was phenotypically confirmed for MBL production.
Like other BLIs, Avibactam is designed to protect beta-lactam antibiotics such as penicillins, cephalosporins and carbapenems from being destroyed by beta-lactamase enzymes that bacteria produce to defend themselves.
Carbapenems are a group of broad-spectrum [beta]-lactams of last resort for the treatment of infections caused by multiresistant bacteria due to their high capacity of entry, low toxicity, high affinity for penicillin-binding proteins (PBP's) and stability against [beta]-lactamases (2).
Carbapenems are our "end of the line" antibiotics for some of our most common bacteria responsible for sepsis such as E.
[4] As carbapenems are the considered to be the potent antimicrobial agent against multidrug-resistant P.