Scientists identified a small number of genes that can cause resistance to carbapenem
antibiotics when expressed.
Over the previous couple of years, Metallo-beta-lactamase producing Gram Negative Rods are being notifiable with the increasing frequency from various parts of the world and they seems as a most generally circulated and have carbapenem
[Bla.sub.IMP] and [bla.sub.VIM] mediated carbapenem
resistance in Pseudomonas and Acinetobacter species in India.
Multiple studies have reported carbapenem
resis-tance from Pakistan7,8.
Pseudomonas aeruginosa (18%) showed highest susceptibility of 87% Sensitivity to Cefepime Tazobactam, Cefepime, Carbapenem
and Amikacin followed by 70% Sensitivity to Piperacillin Tazobactam and Cefoperazone sulbactam.
polymyxin B combined with a carbapenem
was not more effective than monotherapy in carbapenem-resistant Gram-negative bacterial infections.
* not all carbapenem
resistance is due to carbapenemase production, and
One of the limitations of this study is that the result was not verified with molecular techniques, as the main aim of the study was to present data on the carbapenem
resistance among Gram negative bacteria.
Although the determination of carbapenem
MIC breakpoints suggested by the European Committee on Antimicrobial Susceptibility Testing (EUCAST) is sometimes useful for predicting CP-GNB, some CP-GNB isolates remain susceptible or intermediate to many carbapenems
According to the Centers for Disease Control and Prevention (CDC), the emergence and dissemination of carbapenem
resistance among Enterobacteriaceae in the U.S.
aeruginosa from strains with other mechanisms responsible for carbapenem
Resistance to carbapenem
was 174(79%) in Klebsiella pneumoniae and 14(5.4%) in Escherichia coli.