carbachol


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carbachol

 [kahr´bah-kol]
a cholinergic agonist that is not hydrolyzed by acetylcholinesterase or pseudocholinesterase; it is used as a miotic and to lower intraocular pressure in treatment of glaucoma and after cataract surgery.

carbachol

A cholinergic agonist, which acts on muscarinic and nicotinic receptors. It is used in ophthalmology to manage glaucoma and in ophthalmic surgery.

Contraindications
Carbachol’s parasympathomimetic effect precludes its use in patients with asthma, bradycardia, hypotension, coronary artery disease, peptic ulcers and urinary incontinence.

carbachol

A parasympathomimetic formed by substituting an acetyl with a carbamyl group on acetylcholine, which acts on muscarinic and nicotinic receptors

carbachol

A drug with ACETYL CHOLINE-like properties of stimulating the PARASYMPATHETIC NERVOUS SYSTEM. It is used to stimulate PERISTALSIS in the intestine, to treat retention of urine and sometimes to treat GLAUCOMA.

parasympathomimetic drug 

A drug with an action resembling that caused by stimulation of the parasympathetic nervous system. Example: a miotic of which there are two types: a direct-acting cholinergic, such as pilocarpine or carbachol; and the other, indirect-acting anticholinesterase, such as physostigmine, neostigmine, echothiophate iodide, demecarium bromide. Syn. cholinergic drug. See miotics.
References in periodicals archive ?
Following preincubation, they were then exposed to 1.1 mM or 20 mM glucose with or without 10 [micro]M carbachol (Meilun) or 10 [micro]M atropine sulfate (Meilun) for 60 min.
Caption: Figure 6: (a) Aorta and (b) mesenteric artery relaxation to cumulative doses of carbachol (* p < 0.05 and *** p < 0.001 WKY versus SHR; ### p < 0.001 WKY versus SHR MOI; $$$ p < 0.001 SHR versus SHR MOI, n = 5 for each group of vessels, values are expressed as mean [+ or -] S.E.M for each dose of carbachol).
Darifenacin hydrobromide, carbachol and other unspecified chemicals were purchased from Sigma-Aldrich Co.
This study was undertaken to compare the effects of extract from fruits of medicinal plant Ammi visnaga which contains natural calcium channel blocker and verapamil on volume and acidity of carbachol induced gastric secretion.
reported in hippocampal slices that a cholinergic agonist, carbachol, suppressed inhibitory synaptic transmission to CA1 pyramidal cells in a C[B.sub.1]R-dependent manner.
It produced nonspecific relaxation of both the carbachol (1 M) and high K+ (80 mM)-induced contractions in isolated trachea of rabbit and guinea-pig in a manner comparable to verapamil.
Effects of intracameral administration of carbachol on postoperactive increase in intraocular pressure in dogs undergoing cataract extraction.
Treated and control cultures of conjunctival goblet cells were stimulated with the cholinergic agonist carbachol ([10.sup.-3] M, Sigma-Aldrich) for one hour and then MUC5AC secretion was measured in the sup ernatants using the Mucin-5 Subtype AC (MUC5AC) ELISA kit (TSZ ELISA, Waltham, MA) according to the manufacturer's instructions.
Effect of mineral salts, carbachol, and pilocarpine on nutrient digestibility and ruminal characteristics in cattle.
Carbachol is another miotic that is prescribed in drop form.