TRPV1

(redirected from Capsaicin receptor)

TRPV1

A gene on chromosome 17p13.2 that encodes a protein which is a receptor for capsaicin and the structurally related vanilloids, and is a non-selective cation channel structurally related to the TRP family of ion channels. The receptor is also activated by high temperatures, suggesting that it functions as a transducer of noxious chemical and painful thermal stimuli in vivo.
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Its mechanism of action could be related with the capsaicin receptor, the Transient Receptor Potential Vanilloid 1 (TRPV1), for its role in the transmission of pain (Carnevale & Rohacs, 2016).
It works by targeting the capsaicin receptor (also known as TRPV1) to inactivate the nerve fibers transmitting pain signals to the brain a therapeutic effect that can last for months until the nerve fiber regenerates.
There is a receptor on the nerves called TRPV1 (transient receptor potential cation channel, subfamily V [vanilloid], member 1), whose previous name was the capsaicin receptor.
In fact, TRPV1 is often called the capsaicin receptor.
20] Yiangou Y, Facer P, Ford A, Brady C, Wiseman O, Fowler CJ et al Capsaicin receptor VR1 and ATP-gated ion channel [P.
Burning mouth syndrome as a trigeminal small fibre neuropathy: increased heat and capsaicin receptor TRPV1 in nerve fibres correlates with pain score.
Other recent studies have shown that some itch inducers -- called pruritogens -- lead to activation of the capsaicin receptor, a pain receptor named for the incendiary chemical in chili peppers.
Impaired nociception and pain in mice lacking the capsaicin receptor.
University of California (Oakland, CA) has patented vanilloid receptor polypeptides and vanilloid receptor-related polypeptides, specifically the capsaicin receptor subtypes VR1 and VR2, as well as the encoding polynucleotide sequences.
After years of looking, researchers recently reported that they had finally identified the capsaicin receptor.
His group has cloned a number of neurotransmitter receptors and ion channels, including the capsaicin receptor, an integrator of multiple pain-producing stimuli.