accumulation

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accumulation

A build-up, assembly; the process of accumulating, collecting together.
 
Medspeak
The progressive increase in the concentration of a chemical, drug, or other agent in an organism or tissue, due to higher doses than can be metabolised, or due to poor metabolism of the agent; the amount of a drug or therapeutic agent in the body, which after the drug has reached a state of equilibrium, is a function of the dose interval and the drug’s T1⁄2.

Equilibrium usually requires a time interval of 4- to 6-times the drug’s half-life, and depends on the rates of absorption and elimination; the drug continues to accumulate until the amount of drug administered in a time period equals that eliminated in the same period.
 
Factors in accumulation
Selective binding of the drug in tissues, concentration of fat soluble drugs in fat, absent or slow metabolism of the drug, slow excretion of the drug, and intercurrent illness; accumulation continues until the amount eliminated per dosage interval is equal to the amount administered during that time.

accumulation

A build-up, assembly; the process of accumulating, collecting together Therapeutics The amount of drug in the body relative to the amount lost by elimination, which is a function of ratio of the dose interval and the drug's half-life; accumulation continues until the amount eliminated per dosage interval is equal to the amount administered during that time. Cf Absorption.
References in periodicals archive ?
THE ALLEGED LOSS OF TIME WHEN CAPITAL ACCUMULATION STEMS FROM CASH BUILDING
Hence, social capital accumulation requires that human capital be allocated to its production, but at each point in time it will also depend on the current stock of social capital, i.
This boom lead to a substantial process of capital accumulation and knowledge transfer since at the time the oil industry was open to foreign direct investment.
For example, if an economy is growing faster than others because of rapid capital accumulation (also referred to as capital deepening), MFP growth in this economy will be low and the long-run prospect for living standards improvements are reduced.
Pioneering contributions in the literature on constrained efficient allocations with private information abstracted from capital accumulation, as the main goal was to study wealth distribution.
It suggests that, in the state sector, capital accumulation played a much more important role than TFP growth in recent years.
PHI] > 0 represents the growth rate of human capital if individuals devote all their time to human capital accumulation.
In reality, however, a sizable fraction of adults does not participate in the labor force, and this fraction varies widely with the level of human capital accumulation.
Only Hashima completely succeeded in forcing the viewer's complicity in creating and sustaining its narrative suspense, in rhapsodizing and proselytizing in equal measure the picturesque, fantastical sight--and accompanying sounds--of capital accumulation pushed beyond its capacity.
Successive chapters review the work that has been done on capital accumulation, the role of human capital, the contribution of technological innovation, entrepreneurship and international trade.
The heavy burdens of rents and dues, the farm holder's financial obligations to his parents and siblings, and, not least, the recurrent cycles of poor and mediocre harvests, imposed powerful constraints on capital accumulation in Stavenow.
Section 3 highlights the policy implications of the discussion in section 2, focusing on the link between the process of capital accumulation and sustainable growth and poverty-reduction.

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