Capillary Leak Syndrome


Also found in: Dictionary, Thesaurus, Acronyms, Encyclopedia, Wikipedia.
A condition in which the size of the pores in the capillaries are increased, leading to a leakage of 10+ litres of fluid into the interstitial space, resulting in haemoconcentration, hypoalbuminaemia, severe hypotension, generalised oedema and multiple organ failure— cardiopulmonary collapse, and acute renal failure—due to acute tubular necrosis following hypovolemia, rhabdomyolysis, due to reduced perfusion, causing progressive dyspnea and pericarditis, high fever, confusion, and disorientation
Aetiology Cytokine therapy with IL-2, GM-CSF, used to treat metastatic cancer
Prognosis The high mortality in early reports has been reduced by prophylactic therapy using terbutaline, theophyllin
References in periodicals archive ?
Capillary leak syndrome was noted among 3 patients and 1 of them had moderate to severe renal failure also.
The important causes of late onset hypotension are hypovolemia, DIC and capillary leak syndrome. Renal failure is common in viperidae bites.
The systemic capillary leak syndrome (SCLS) is characterized by spontaneous recurrent episodes of hypotension, haemoconcentration, generalized oedema, and in most cases, the presence of a paraprotein.
A capillary leak syndrome was considered on the basis of severe hypovolaemic shock, oedema, haemoconcentration, and low albumin level.
In a series of eight patients, Tahirkheli and greipp from the mayo Clinic showed treatment with theophylline and terbutaline caused episodes of the systemic capillary leak syndrome to completely abate in some patients and decreased the incidence and severity of episodes in others (5).
Capillary leak syndrome in a 5-month-old infant associated with intractable diarrhoea.