Capillary Leak Syndrome


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A condition in which the size of the pores in the capillaries are increased, leading to a leakage of 10+ litres of fluid into the interstitial space, resulting in haemoconcentration, hypoalbuminaemia, severe hypotension, generalised oedema and multiple organ failure— cardiopulmonary collapse, and acute renal failure—due to acute tubular necrosis following hypovolemia, rhabdomyolysis, due to reduced perfusion, causing progressive dyspnea and pericarditis, high fever, confusion, and disorientation
Aetiology Cytokine therapy with IL-2, GM-CSF, used to treat metastatic cancer
Prognosis The high mortality in early reports has been reduced by prophylactic therapy using terbutaline, theophyllin
References in periodicals archive ?
The important causes of late onset hypotension are hypovolemia, DIC and capillary leak syndrome.
A hematocrit value of more than 40 is associated with capillary leak syndrome, hypotension and renal failure.
Other causes of late onset hypotension are haemo concentration due to capillary leak syndrome.
In a series of eight patients, Tahirkheli and greipp from the mayo Clinic showed treatment with theophylline and terbutaline caused episodes of the systemic capillary leak syndrome to completely abate in some patients and decreased the incidence and severity of episodes in others (5).
Idiopathic capillary leak syndrome complicated by massive rhabdomyolysis.
The most common serious side effects were capillary leak syndrome (11%), infusion reactions (8%), and visual changes including loss of visual acuity (4%).