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a synthetic corticosteroid used topically as f. acetonide for the relief of inflammation and pruritus in certain dermatoses.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.


(floo-oh-sin-oh-lone) ,


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Therapeutic: anti inflammatories steroidal
Pharmacologic: corticosteroids
Pregnancy Category: C


Management of inflammation and pruritis associated with various allergic/immunologic skin problems.


Suppresses normal immune response and inflammation.

Therapeutic effects

Suppression of dermatologic inflammation and immune processes.


Absorption: Minimal. Prolonged use on large surface areas, application of large amounts, or use of occlusive dressings may increase systemic absorption.
Distribution: Remains primarily at site of action.
Metabolism and Excretion: Usually metabolized in skin.
Half-life: Unknown.

Time/action profile (response depends on condition being treated)



Contraindicated in: Hypersensitivity or known intolerance to corticosteroids or components of vehicles (ointment or cream base, preservative, alcohol); Untreated bacterial or viral infections.
Use Cautiously in: Hepatic dysfunction; Diabetes mellitus, cataracts, glaucoma, or tuberculosis (use of large amounts of high-potency agents may worsen condition); Patients with pre-existing skin atrophy; Pregnancy, lactation, or children (chronic high-dose usage may result in adrenal suppression in mother, growth suppression in children; children may be more susceptible to adrenal and growth suppression).

Adverse Reactions/Side Effects


  • allergic contact dermatitis
  • atrophy
  • burning
  • dryness
  • edema
  • folliculitis
  • hypersensitivity reactions
  • hypertrichosis
  • hypopigmentation
  • irritation
  • maceration
  • miliaria
  • perioral dermatitis
  • secondary infection
  • striae


  • adrenal suppression (use of occlusive dressings, long-term therapy)


Drug-Drug interaction

None significant.


Topical (Adults) Apply to affected area(s) 2–5 times daily (depends on preparation and condition being treated).
Topical (Children ≥2 yr) Apply to affected area(s) 1–2 times daily (depends on product, preparation, and condition being treated).

Availability (generic available)

Cream: 0.01%, 0.025%
Ointment: 0.025%
Solution: 0.01%
Shampoo: 0.01%
Oil: 0.01%
In combination with: hydroquinone and tretinoin (Tri-Luma). See combination drugs.

Nursing implications

Nursing assessment

  • Assess affected skin before and daily during therapy. Note degree of inflammation and pruritus. Notify health care professional if symptoms of infection (increased pain, erythema, purulent exudate) develop.
  • Lab Test Considerations: Periodic adrenal function tests may be ordered to assess degree of hypothalamic-pituitary-adrenal (HPA) axis suppression in chronic topical therapy if suspected. Children and patients with dose applied to a large area, using an occlusive dressing, or using high-potency products are at highest risk for HPA suppression.
    • May cause increased serum and urine glucose concentrations if significant absorption occurs.

Potential Nursing Diagnoses

Risk for impaired skin integrity (Indications)
Risk for infection (Side Effects)
Deficient knowledge, related to medication regimen (Patient/Family Teaching)


  • Choice of vehicle depends on site and type of lesion. Ointments are more occlusive and preferred for dry, scaly lesions. Creams should be used on oozing or intertriginous areas, where the occlusive action of ointments might cause folliculitis or maceration. Creams may be preferred for aesthetic reasons even though they may be more drying to skin than ointments. Gels, aerosols, lotions, and solutions are useful in hairy areas.
  • Topical: Apply ointments, creams, orsolutions sparingly as a thin film to clean, slightly moist skin. Wash hands immediately after application. Apply occlusive dressing only if specified by health care professional.
    • Apply shampoo oroil to hair by parting hair and applying a small amount to affected area. Rub in gently. Protect area from washing, clothing, or rubbing until medication has dried. Hair may be washed as usual but not immediately after applying medication.

Patient/Family Teaching

  • Instruct patient on correct technique of medication administration. Emphasize importance of avoiding the eyes. If a dose is missed, it should be applied as soon as remembered unless almost time for the next dose.
  • Caution patient to use only as directed. Avoid using cosmetics, bandages, dressings, or other skin products over the treated area unless directed by health care professional.
  • Advise parents of pediatric patients not to apply tight-fitting diapers or plastic pants on a child treated in the diaper area; these garments work like an occlusive dressing and may cause more of the drug to be absorbed.
  • Advise patient to consult health care professional before using medicine for condition other than indicated.
  • Caution women that medication should not be used extensively, in large amounts, or for protracted periods if they are pregnant or planning to become pregnant.
  • Instruct patient to inform health care professional if symptoms of underlying disease return or worsen or if symptoms of infection develop.

Evaluation/Desired Outcomes

  • Resolution of skin inflammation, pruritus, or other dermatologic conditions.
Drug Guide, © 2015 Farlex and Partners


A powerful CORTICOSTEROID drug used for external applications. A brand name is Synalar. It is marketed with other ingredients as Synalar C and Synalar N.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
References in periodicals archive ?
The risk rises as the size of capex increases, because larger capex requires longer time for a company to recover its investment thereby, raising the uncertainty of realizing a positive NPV or IRR.
Matt Walker, a principal analyst at Ovum's networks practice, said: "Economic worries caused budget cuts late in the year, hitting SP capex. Overall for 2011, capex grew 9% to $306 billion, due to double-digit percentage growth in the first three quarters; capex declined 1% year-over-year in 4Q11.
In a new report, the telecoms analyst found that service provider (SP) capex and revenues grew an estimated 12 per cent and seven per cent respectively in 2011, with capex reaching $314bn and revenues $1,962bn.
National Oil companies and integrated oil companies will be key spenders, contributing 85% to the global oil and gas capex in 2011.
19 October 2011 - Swedish telecoms group Tele2 AB (STO:TEL2 B) cut its capex forecast and said investments would not exceed SEK5bn this year, in its third-quarter report, published today.
It is worth noting that, this reduction in mobile CapEx concerned all regions.
International Resource News-January 25, 2011--Severn Trent PLC expects net capex to be GBP400m to GBP410m(C)1994-2011 ENPublishing - http://www.enpublishing.co.uk
The study also says Azerbaijan should remain the largest offshore producer of both oil and gas in the Caspian Sea, and also leads the way in capex, with Kazakhstan, Russia, and Turkmenistan each expected to contribute $1.6-2 billion over the forecast period.
The report says that almost 173,000 km of hydrocarbons trunk pipelines will be constructed over the period of 2011 to 2015 with a total capital cost exceeding $193 billion, a 14 per cent Capex increase and an 11.4 per cent increase in length relative to 2006 to 2010 when more than 155,000 km of oil, gas and product pipelines were installed globally requiring a Capex of almost $169 billion.
"The sharp rebound in capex reflects a combination of improved demand conditions, particularly in commodity driven sectors, and the success of steps companies took to strengthen their balance sheets during 2009," said Alex Griffiths, Fitch's Head of International Research for EMEA and Asia Pacific corporates.
The outlook revision reflects the benefits that the firm is expected to derive from scaled-up operations following the recent equity-funded capital expenditure (capex).
Kearney, one of the world's leading management consulting firms in the Telecom industry has identified that regional telecom operators may reap significant benefits by implementing cost and CapEx optimisation programs.