Endocannabinoids, also known as endogenous cannabinoids, signal molecules deriving from lipid precursors that exhibit their effects when activating cannabinoid receptors
(CB1 and CB2).
Anandamide binds to type 1 cannabinoid receptors
(CB1), which are also activated by THC, the main psychoactive cannabinoid in marijuana.
More recently, cannabinoid research in his laboratory led to the discovery that cannabinoid receptors
that mediate the cannabis-induced "high" and also many of the often beneficial effects of endocannabinoids, contain allosteric sites.
A cannabinoid is a class of chemical compounds that change the neurotransmitter release in the brain by acting on cannabinoid receptors
in the cells.
Overexpression of cannabinoid receptors
in malignant prostate tissue can be an alternative option for the treatment of prostate cancer.
Synthetic cannabinoids (SC) are a heterogeneous group of substances with high affinity for cannabinoid receptors
. They represent an emerging class of new drugs, the use of which has been expanding rapidly in recent years (Ford, Tai, Fantegrossi & Prather, 2017).
The endogenous cannabinoid or endocannabinoid system includes cannabinoid receptors
, associated endogenous ligands (such as arachidonoyl ethanolamide [anandamide or AEA], 2-arachidonoyl glycerol [2AG], and N-palmitoylethanolamide [PEA], a fatty acid amide that enhances AEA activity), (2) and enzymes involved in endocannabinoid production and decay.
Dogs, in particular, have plenty of cannabinoid receptors
all over their body and brain so they are extra sensitive to THC.
There are cannabinoid receptors
found in so many places in our body that the ECS is crucial to our optimal health.
Its medicinal properties have been reported for centuries but only recently it started being prescribed for pain after the discovery of endogenous cannabinoid receptors
(BONFA et al., 2008; LESSA et al., 2016).
(17) Other undiscovered cannabinoid receptors
may exist, and these receptors may partly mediate some of the analgesic effects associated with cannabinoids.
To understand the biology behind the intense reaction to Spice we need to look at the parts of the body's central nervous system that react to cannabis - the cannabinoid receptors
- and the chemical part of the drug that reacts with the body - the "agonist".