hereditary nonpolyposis colorectal cancer

(redirected from Cancer Family syndrome)

hereditary nonpolyposis colorectal cancer

an autosomal dominant predisposition to early-onset colorectal cancer in the absence of adenomatosis. The disease phenotype may be limited to the colorectum (Lynch syndrome I) or coexist with extracolonic tumors such as endometrial or gastric cancer among others (Lynch syndrome II). The genetic basis is in one of several genes responsible for DNA mismatch repair; in over 90% of cases, the mutation is one of two genes: MSH2 and MLH1.
Farlex Partner Medical Dictionary © Farlex 2012

he·red·i·tar·y non·pol·y·po·sis co·lo·rec·tal can·cer

(hĕr-ed'i-tar-ē non'pol-i-pō'sis kō'lŏr-ek'tăl kan'sĕr)
An autosomal dominant predisposition to cancer of the colon and rectum.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
References in periodicals archive ?
Our patient does not fulfill the criteria of cancer family syndrome; therefore, no genetic testing was done to her [7].
Histopathology of colorectal carcinomas and adenomas in cancer family syndrome. Dis Colon Rectum.
Organized into nine chapters, each beginning with a summary of key points, the reference covers the epidemiology of the disease, up to date information on ovarian cancer family syndrome, options for genetic testing, basic principles of cancer screening, latest developments in radiographic imaging, a review of surgical methods of intervention, and chemotherapy treatment regime recommendations.

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