An endophytic fungus from Camptotheca
acuminata that produces camptothecin and analogues.
CZ48 is an analog synthesized by the Stehlin Foundation from Camptothecin, an alkaloid extracted from the Chinese tree camptotheca
acuminata, and frequently Lindera Thunb.
New camptothecin and ellagic acid analogues from the root bark of Camptotheca
The chemical created so much excitement that the government turned over federal land in Chico to cultivate Camptotheca
acuminata, the Chinese shrub from which camptothecin was derived.
Karyomorphology of Davidia involucrata and Camptotheca
acuminata, with special reference to their systematic positions.
Isolation and identification of the 10-hydroxycamptothecin-producing endophytic fungi from Camptotheca
Topotecan, to be marketed as Hycamtin by SmithKline Beecham Pharmaceuticals, is derived from the bark of a Chinese tree known scientifically as Camptotheca
Among others we can cite as plant-derived drugs, vincristine isolated from Catharanthus roseus, paclitaxel isolated from Taxus brevifolia, irinotecan, which is a hemisynthetic derivative of camptothecin isolated from Camptotheca
acuminata, and etoposide, which is a hemisynthetic derivative of a compound isolated from Podophyllum.
CPT-11 is a camptothecin analog obtained from the Chinese tree camptotheca
acuminata that kills tumor cells by inhibiting the nuclear enzyme topoisomerase I and interrupting the DNA replication process.
These derivatives are less stable and may not be as effective as neat camptothecin derived from the Chinese tree, Camptotheca
CPT was first isolated from the bark of the Chinese tree, Camptotheca