irinotecan

(redirected from Camptosar)

irinotecan

/iri·no·te·can/ (i″rĭ-no-te´kan) a DNA topoisomerase inhibitor used as the hydrochloride salt as an antineoplastic in the treatment of colorectal carcinoma.

irinotecan

an antineoplastic hormone.
indication It is used to treat metastatic carcinoma of the colon or rectum.
contraindications Pregnancy and known hypersensitivity to this drug prohibit its use.
adverse effects Life-threatening effects include leukopenia, anemia, and neutropenia. Other adverse effects include fever, headache, chills, dizziness, diarrhea, nausea, vomiting, anorexia, constipation, cramps, flatus, stomatitis, dyspepsia, site irritation, rash, sweating, dyspnea, increased cough, rhinitis, vasodilation, edema, asthenia, and weight loss.

irinotecan

A topoisomerase-1 inhibitor and semisynthetic analogue of the natural alkaloid camptothecin, which is activated by hydrolysis in vivo to an active metabolit, SN-38, and inactivated by glucuronidation with uridine diphosphate glucoronosyltransferase 1A1 (UGT1A1). It was FDA-approved for managing colorectal carcinoma in 1994. 

Adverse effects
Severe diarrhoea, possibly leading to dehydration, requiring aggressive antidiarrhoeal management with loperamide or Lomotil; immunosuppression with severe neutropaenia; functional overdose in patients who under-express UGT1A1 and cannot clear irinotecan as quickly (e.g., those with Gilbert syndrome as normal patients).

irinotecan

An anticancer drug used to treat widespread secondary cancer of the colon or rectum. A brand name is Campto.
References in periodicals archive ?
Recent pharmacokinetic (PK) data from its ongoing Phase 1 clinical study of IT-141 showed successful delivery of SN-38 far in excess of both Pfizer's Camptosar (irinotecan) and Merrimack's Onivyde (liposomal irinotecan), the latter of which was acquired by Ipsen in early 2017.
Two synthetic forms, marketed as Camptosar and Hycamtin, are used in chemotherapy treatments today.
If the cancer relapses from two to six months after treatment, your health care professional may try Hycamtin, Camptosar, cyclophosphamide/doxorubicin/vincristine (known as the CAV regimen), Gemzar, Taxol, Taxotere, oral VePesid or Navelbine.
s Camptosar (irinotecan hydrochloride), an injectable drug used to treat patients with colorectal cancer.
2 billion, or 44%, due to legacy Wyeth products, and negatively impacted by $458 million, or 4%, due to legacy Pfizer products, including the loss of exclusivity of Lipitor in Canada and Spain, as well as Camptosar in Europe.
Until joining the International Genomics Consortium (IGC), he led a multi-disciplinary group providing high quality Pharmacogenomic support across therapeutic areas for research and clinical trials including development of Lipitor, Lyrica, Detrol, Camptosar, Sutent, and Chantix.
The committee expressed low confidence in CYP2D6 gene testing (for example, Roche's AmpliChip) to guide tamoxifen treatment of breast cancer, UGTlAl assays for selecting doses of Pfizer's colon cancer drug Camptosar (irinotecan), and pharmacogenomic tests based on the BCR-ABL gene to identify point mutations in CML patients.
Prior to CVT, Fong directed several sales teams and has previous oncology experience launching Camptosar at Pharmacia.
With his prior expertise in marketing and sales, and the launch of a novel blockbuster anti-cancer agent Camptosar, Jim has the ideal credentials to lead a successful sales and marketing effort for Zevalin while optimizing the positioning of our future oncology products like pixantrone," noted Dr.
The Cetuximab Combined with Irinotecan in First Line Therapy for Metastatic Colorectal Cancer (CRYSTAL) and the Bolus Infusion Capecitabine Camptosar with Celebrex (BICC-C) studies are two large trials that have reported results from first-line treatment combination of cetuximab and FOLFIRI.
The other drugs reviewed that also had no new safety concerns were anti-neoplastic agent Camptosar (irinotecan), antineoplastic agent Paraplatin (carboplatin), platelet-reducing agent Agrylin (anagrelide), and hematinic agent Ferrlecit (sodium ferric gluconate complex).
She is to continue on a chemotherapy regimen of Camptosar, Leucovorin, and 5FU.