Lexi Pharma team members have collectively filed 15 New Drug Applications and have been involved in the development and launch of successfully marketed products including: Byetta, Bydureon, Camptosar
, Dacogen, Ellence, Emcyt, Erbitux, Folotyn, Panretin, Symlin, Sutent, Targretin, Vidaza, Velcade, and Zarnestra.
Then, a combination of leucovorin (Leucovorin Atafarm, Novartis)/fluorouracil (5-florourasil, Sandoz)/irinotecan (Camptosar
, Pfizer) (Folfiri) was administered.
Recent pharmacokinetic (PK) data from its ongoing Phase 1 clinical study of IT-141 showed successful delivery of SN-38 far in excess of both Pfizer's Camptosar
(irinotecan) and Merrimack's Onivyde (liposomal irinotecan), the latter of which was acquired by Ipsen in early 2017.
[prescribing information], 2017, http://labeling.pfizer .com/ShowLabeling.aspx?id=533.
Irinotecan is (CPT-11) activated by hydrolysis to SN-38, an inhibitor of (Camptosar
) topoisomerase I and, thus, blocks replication and transcription.
Two synthetic forms, marketed as Camptosar
and Hycamtin, are used in chemotherapy treatments today.
In 2000, irinotecan (Camptosar
, Pfizer) given with bolus 5-FU and leucovorin injection (IFL regimen) was shown to improve median overall survival in previously untreated patients with metastatic colorectal cancer from 12.6 to 14.8 months versus 5-FU and leucovorin alone.
Modern pharmacology doesn't resign itself to the inevitability of side effects; it tracks them to the molecular variations that make some people allergic to aspirin, for example, and others unable to tolerate Camptosar
, a powerful cancer drug.
* Irinotecan (Camptosar
): This drug is often combined with 5-FU and leucovorin in a regimen called FOLFIRI.
TPMT ** Tabloid,  thioguanine (GlaxoSmithKine) DPD ** Xeloda,  capecitabine (Hoffman La Roche Inc.) ER-PGR ** Aromasin,  exemestane (Pfizer) G6PD ** Elitek,  rasburicase (Sanofi- synthelabo Inc.) ER * Nolvadex,  tamoxifen (AstraZeneca) ER * Arimidex,  anastrozole (AstraZeneca) ER ** Faslodex,  fulvestrant (AstraZeneca) UGT1A1 ** Camptosar
,  irinotecan (Pfizer) ERCC1 * Camptosar
,  irinotecan (Pfizer) tpmt * Platinol,  cisplatin, (Bristol-Myers Squibb Company) tpmt ** Tabloid,  thioguanine (GlaxoSmithKline) CDK 4 and 6 * Palbociclib, PD-  0332991 (Pfizer) * This biomarkers are used for diagnostic and prognostic purposes to determine the proper cause of treatment (investigational diagnostics and/or drugs).
A case in point, they say, is Pfizer Inc.'s Camptosar
(irinotecan hydrochloride), an injectable drug used to treat patients with colorectal cancer.
Comments: Revenues in the quarter were boosted by $5.2 billion, or 44%, due to legacy Wyeth products, and negatively impacted by $458 million, or 4%, due to legacy Pfizer products, including the loss of exclusivity of Lipitor in Canada and Spain, as well as Camptosar