CAMK4

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CAMK4

A gene on chromosome 5q21.3 that encodes a multifunctional serine/threonine protein kinase, which is part of the calcium-triggered CaMKK-CaMK4 signalling cascade and regulates, mainly by phosphorylation, the activity of transcription activators (e.g., CREB1, MEF2D, JUN and RORA). These activators play key roles in immune response, inflammation and memory consodilation. In the thymus, CAMK4 regulates the CD4/CD8 (double positive thymocytes) selection threshold during T-cell ontogeny; it also play a role in transcriptional regulation in lymphocytes, neurons and male germ cells, and is expressed in the brain, thymus, CD4 T-cells and in epithelial ovarian cancers.
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Previous reports demonstrated that treatment of cultured hippocampal neurons with the CaMK kinase inhibitor STO-609 (2-5 [micro]M) inhibits CaMKI but not CaMKII (Wayman et al.
This unique collection of 84 structurally diverse and potent inhibitors, which mainly target the CMGC, CaMK, AGC and STE families of kinases, serves as a complement to the InhibitorSelect[TM] 96-well Protein Kinase Library II.
2+]/calmod-ulin-dependent protein kinase (CaMK); (ii) CaMK stimulates NOS to synthesize NO, which activates GC-S, leading to cGMP synthesis and release into the cytosol; (iii) cGMP activates PKG, which regulates myosin molecular motor activity, leading to granule translocation along the actin filaments constituting the cytoskeleton; (iv) myosin activity is determined by the degree of MLC phosphorylation/de-phosphorylation, which is controlled by the regulatory proteins MLCK, ROCK, and MLCP; and (v) RPCH uncoupling from the receptor leads to PDES-mediated reduction in cGMP concentration and PKG deactivation.
Involvement of Ca2+, CaMK II and PKA in EGb 761-induced insulin secretion in INS-1 cells.
One of the major transcription factors that recognizes the CRE is a protein called CRE-binding protein (CREB1), which functions as a transcriptional activator only after it is phosphorylated by either PKA, MAPK, or CamK.