norethindrone acetate

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norethindrone acetate

Aygestin, Camila, Errin, Jolivette, Nora-BE, Nor-QD, Ortho Micronor

Pharmacologic class: Progesterone, hormone

Therapeutic class: Progestin

Pregnancy risk category X


Inhibits pituitary gonadotropin secretion, suppressing follicular maturation and ovulation and stimulating mammary tissue growth


Tablets: 0.35 mg, 5 mg

Indications and dosages


Adults: 5 mg Aygestin P.O. daily for 2 weeks, increased in increments of 2.5 mg/day q 2 weeks until 15 mg daily is reached

Amenorrhea; abnormal uterine bleeding

Adults: 2.5 to 10 mg Aygestin P.O. daily starting on day 5 of menstrual cycle

Prevention of pregnancy

Adults: 1 tablet (0.35 mg) P.O. daily


• Hypersensitivity to drug

• Impaired liver function or liver disease

• Thromboembolic disorders

• Known or suspected breast cancer

• Undiagnosed vaginal bleeding

• Known or suspected pregnancy

• As a diagnostic test for pregnancy


Use cautiously in:

• hypertension, blood dyscrasias, bone marrow disease, hepatic or renal disease, gallbladder disease, heart failure, diabetes mellitus, depression, migraine, asthma, seizure disorder

• family history of breast or reproductive tract cancer

• breastfeeding patients.


• Give with or without food.

• When administering for endometriosis, amenorrhea, or abnormal uterine bleeding, know that therapy may continue for 6 to 9 months or until breakthrough bleeding necessitates a temporary halt.

• When administering for prevention of pregnancy, know that drug must be given continuously every day at the same time with no interruptions between pill packs.

Adverse reactions

CNS: migraine, depression, insomnia, drowsiness

EENT: retinal vascular lesions, sudden partial or complete vision loss, proptosis, diplopia, papilledema

GI: nausea

GU: breakthrough bleeding, menstrual flow changes, amenorrhea, changes in cervical erosion and secretions, breast tenderness and secretion

Hepatic: cholestatic jaundice

Metabolic: fluid retention, decreased glucose tolerance

Skin: rash, urticaria, acne, hirsutism, chloasma

Other: edema, weight gain or loss, fever


Drug-drug. Hepatic enzyme-inducing drugs (such as carbamazepine, phenobarbital, phenytoin, rifampin): decreased norethindrone efficacy

Drug-diagnostic tests. Alkaline phosphatase; amino acids; factors VII, VIII, IX, and X; nitrogen; pregnanediol: increased levels

Gamma-glutamyltransferase, high-density lipoproteins: decreased levels

Drug-herbs. Cola nut, guarana, yerba maté: increased CNS stimulation St. John's wort: decreased contraceptive efficacy

Drug-behaviors. Smoking: risk of serious cardiovascular reactions

Patient monitoring

• Monitor pretreatment and annual physical exams to check blood pressure, breasts, abdomen, pelvic organs, and Pap smear results.

Assess for signs and symptoms of depression, especially in patients with history of depression. Stop giving drug if significant depression recurs.

• Check blood glucose level in diabetic patients.

Patient teaching

• Instruct patient to avoid pregnancy or to discontinue drug if she gets pregnant (may cause serious fetal anomalies or fetal death).

Advise patient to discontinue drug and consult prescriber if she experiences sudden partial or complete vision loss.

• If patient is receiving drug to treat amenorrhea, tell her to mark administration days on calendar.

• Instruct patient taking drug to prevent pregnancy to take drug every day at the same time without interruption between pill packs.

• Tell diabetic patient to monitor blood glucose level closely and to watch for hyperglycemia.

• Instruct patient to report breakthrough bleeding, spotting, change in menstrual flow, or amenorrhea.

• Caution patient not to smoke during therapy.

• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, tests, herbs, and behaviors mentioned above.

References in periodicals archive ?
Lili Reinhart and Camila Mendes who plays Betty and Veronica in Riverdale, respectively expressed their disappointment on a magazine who allegedly photoshopped their waists.
Noting that the "fight is not over", Reinhart posted her photo, as well as those of Camila Mendes (Riverdale's Veronica Lodge), during their February shoot for Cosmopolitan.
Camila Cabello and Taylor Swift may be friends but it looks like the two singers are also about to become business partners.
Former Fifth Harmony member Camila Cabello has been too busy with work the past couple of years that she has had no time for social life.
CAMILA CABELLO CAMILA HHHHH SIR Elton John predicted 2018 would be "an amazing year" for Camila Cabello - If her debut, self-titled album is anything to go by, it's an apt statement.
Gomez's fans noticed that the Wolves singer also stopped following Camila Cabello, her former Wizards of Waverly Place co-stars and the cast of 13 Reasons Why .
El oscarizado actor y su mujer, Camila Alves, se lo pasaron en grande en el parque Walt Disney de Lake Buena Vista, de Florida, aunque los que mas se divirtieron fueron sus dos hijos mayores, Levi, de 9 anos, y Vida, que cumplira 8 en enero.
THE ex-boss of Kids Company Camila Batmanghelidjh and its former chairman Alan Yentob face being banned from running companies for up to six years.
WHAT to make of Camila Batmanghelidjh and her apparently supersize ego?
WE LOVE DOCUMENTARY CAMILA'S KIDS COMPANY: THE INSIDE STORY (BBC1, 9pm) FILMMAKER Lynn Alleway had a major coup when Kids Company founder Camila Batmanghelidjh, below, asked her to follow her for a documentary.